N. prodotti: 0
Totale ordine: € 0,00
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Online ISSN 1827-1928
EPIDEMIOLOGY AND CLINICAL MEDICINE
Liao H. F. 1, 2, 3, Chiang L. M. 2, Yen C. C. 2, Chen Y. Y. 4, Zhuang R. R. 5, Lai L. Y. 6, Chiang J. 2, Chen Y. J. 2, 7
1 Department of Medical Research Mackay Memorial Hospital, Taipei, Taiwan
2 Graduate Institute of Sport Coaching Science Chinese Culture University, Taipei, Taiwan
3 Department of Molecular Biology and Biochemistry National Chiayi University, Chiayi, Taiwan
4 Department of Physical Education, National Taiwan College of Physical Education, Taichung, Taiwan
5 Department of Martial Arts Chinese Culture University, Taipei, Taiwan
6 Department of Physical Education Chinese Culture University, Taipei, Taiwan
7 Department of Radiation Oncology Mackay Memorial Hospital, Taipei, Taiwan
Aim. Dendritic cells (DCs) are potent antigen-presenting cells that promote antitumor immunity in vivo when pulsed with tumor antigen. No studies have indicated that exercise training affects DC function. The purpose of this study was to investigate the effect of a 5-week periodized exercise training and active recovery program on the development of DCs, and to test their effect on the antitumor immunity of mononuclear cells (MNC) from blood and spleen against human leukemic U937 and murine lymphoma Yac-1 cells, respectively.
Methods. Male Fisher 344 rats were divided into 2 groups: exercise and non-exercise group. The training protocol consisted of running on a motor-driven treadmill 6 days a week for consecutive 5 weeks, during which the running time, treadmill speed, and incline gradient were increased weekly. Active recovery parameters were set at 30% of the intensity of the previous day.
Results. DC numbers increased significantly (P<0.05) in the exercise group compared to controls, but there were no significant changes in the expression of surface antigens CD80 and CD86. In exercise group MNC-conditioned medium (CM) prepared with 50 µg/mL phytohemagglutinin (PHA) significantly inhibited proliferation of U937 cells, and splenocyte-CM with PHA at 20 and 40 µg/mL significantly inhibited proliferation of YAC-1 cells greater than control group.
Conclusion. The 5-week periodized exercise training with active recovery promotes the number of DCs and enhances the activity of DCs against tumor cells.