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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
Rivista di Medicina, Traumatologia e Psicologia dello Sport
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Original Articles BODY COMPOSITION, SPORT NUTRITION AND SUPPLEMENTATION (ergogenics)
The Journal of Sports Medicine and Physical Fitness 2005 September;45(3):337-46
Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation
Zhou S., 1 Zhang Y. 2, Davie A. 1, Marshall-Gradisnik S. 1, Hu H. 2, Wang J. 1, Brushett D. 3
1 School of Exercise Science and Sport Management Southern Cross University, Lismore, Australia
2 Tianjin Institute of Physical Education, Tianjin, China
3 The Centre for Phytochemistry Southern Cross University, Lismore, Australia
Aim. To investigate whether 4 weeks of oral supplementation with coenzyme Q10 (CoQ10) would increase its concentration in skeletal muscle, and affect aerobic power (V.O2max) and oxygen consumption during submaximal exercise in healthy, physically active men.
Methods. Six volunteers with an average (±SD) age of 29.7±7.2 years and V.O2max of 39.4±8.5 mL.kg-1.min-1, participated in a single-blind trial. The experiment consisted of 4 2-week phases, in the order of placebo run-in, CoQ10 supplementation (150 mg daily), CoQ10 (150 mg) plus vitamin E (1 000 IU daily), and placebo wash-out. A three-stage cycle economy test (4 minutes at each of 50, 100, and 150 watts), followed by a V.O2max test (25 watts increment every minute till exhaustion), were performed prior to the supplementation and at the end of each phase. Blood samples were taken pre and post each V.O2max test, and biopsy samples were obtained from the vastus lateralis muscle pre and post the 4 weeks of CoQ10 supplementation.
Results. The plasma CoQ10 concentration was significantly elevated by the supplementation (P<0.05), however, it did not vary significantly pre and post each exercise test (P>0.05). The muscle CoQ10 concentration, V.O2max ventilatory threshold, exercise economy and oxygen deficit showed no significant changes in response to the supplementation.
Conclusion. It was speculated that the non-significant effects of supplementation in healthy, non CoQ10-deficient men could be due to either that the mitochondrial membrane is normally saturated with CoQ10, or that the selected exercise testing protocol and variables were not sensitive enough to detect the effects.