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Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Online ISSN 1827-1928
Schuler P. B. 1, Leblanc P. A. 2, Marzilli T. S. 1
1 Human Performance Laboratory Department of Health Leisure and Exercise Science University of West Florida, Pensacola, FL, USA
2 Immunology Laboratory, Department of Biological Sciences The University of Alabama, Tuscaloosa, AL, USA
Aim. The purpose of this study was to determine the effect of physical activity on the production of specific antibody in response to a defined antigen, in particular, the hemagglutinin-inhibition response to the H3N2 (A/Sidney/05/97) and H1N1 (A/ Beij-ing/262/95) component of the 1998-99 influenza virus vaccine.
Methods. Thirty older adults aged 67 to 91 years (mean 81±5) participated in the study. Physical activity was assessed using the Physical Activity Scale for the Elderly (PASE); a log-base 2 increase (fold increase) in titer of a serum over the prebleed for each person was representative of the immune response. Plasma samples were collected prior to, 1, 2, 4, and 6 weeks postinfluenza virus vaccination. A repeated measures ANOVA was used to evaluate the overall immune response to the H3N2 and H1N1 components of the influenza virus vaccine. Pearson correlations were used to determine the relationship between specific antibody production and physical activity.
Results. As expected, for both antigens, titers significantly increased after vaccination with the highest titers found six weeks postvaccination. A significant correlation between physical activity and specific antibody production was found for the Sidney component of the vaccine (H3N2) one week post- vaccination (r=0.59; p<0.05).
Conclusion. The results of the present study indicated a positive relationship between physical activity and the initial immune response to a specific antigenic challenge in the present sample of older adults.