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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
Rivista di Medicina, Traumatologia e Psicologia dello Sport
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Original articles EPIDEMIOLOGY AND CLINICAL MEDICINE
The Journal of Sports Medicine and Physical Fitness 2003 Settembre;43(3):393-7
Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats
Yu B. K. 1, Yoon B. C. 2, Kim S. S. 2, Chun S. L. 3, Kim E. H. 4, Kim K. M. 5, Lim B. V. 5, Jang M. H. 5, Chung J. H. 5, Kim C. J. 5
1 Department of Physical Therapy, Shingu College, Kyonggi, Korea
2 Research Institute of Sports Science, Korea University, Seoul, Korea
3 Graduate School of Health Science, College of Medicine, Pochun CHA University, Seoul, Korea
4 Department of Meridianology, College of Oriental Medicine, Semyung University, Chungbuk, Korea
5 Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul, Korea
Aim. Effect of treadmill exercise on hippocampal cell proliferation under normal conditions has been well documented; however, this effect under alcohol intoxication conditions is not clarified, yet. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus in alcohol-intoxicated rats was investigated.
Methods. Experimental design: comparative investigation on number of 5-bromo-2’-deoxyuridine (BrdU)-positive cells in the dentate gyrus 8 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 5 weeks in age weighing 150±10 g. Intervention: animals were divided into 4 groups: the control-rest group, the control-exercise group, the alcohol-treated-rest group, and the alcohol-treated-exercise group. Animals of the alcohol-treated groups were injected intraperitoneally with alcohol (2 g/kg) once a day for 3 days. All animals were injected BrdU (50 mg/kg) intraperitoneally, and rats of exercise groups were made to run on treadmill for 30 min each day for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry.
Results. Treadmill exercise significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation and treadmill exercise alleviated alcohol-induced inhibition of new cell formation.
Conclusion. These results suggest the possibility that treadmill exercise may help in improvement following alcohol-induced brain damage.