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Original articles  IMMUNOLOGY


The Journal of Sports Medicine and Physical Fitness 2003 March;43(1):99-104

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Modulation of immune responses by treadmill exercise in Sprague-Dawley rats

Kim H. 1, Shin M.S. 1, Kim S.S. 1, Lim B.V. 2, Kim H. B. 2, Kim Y.P. 2, Chung J.H. 2, Kim E.H. 3, Kim C.J. 2

1 Research Institute of Sports Science Korea University, Seoul, Korea 2 Kohwang Medical Research Institute College of Medicine, Kyung Hee University, Seoul, Korea 3 Department of Meridianology, College of Oriental Medicine Semyung University, Chungbuk Korea


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Aim. The dura­tion-depen­dence of the ­effect of ­forced tread­mill exer­cise on the ­immune ­system is a sub­ject of ­ongoing ­research. In ­this ­study, the ­effect of ­forced tread­mill exer­cise on ­immune ­responses was inves­ti­gated by eval­u­ating the lym­pho­cyte ­subset frac­tions in the periph­eral ­blood and ­spleen of ­Sprague-­Dawley ­rats.
­Methods. Experi­mental ­design: Com­par­a­tive inves­ti­ga­tion ­over 8 ­weeks. Set­ting: Experi­mental ­animal labor­a­tory. Par­tic­i­pants: ­Male ­Sprague-­Dawley ­rats 5 ­weeks of age, ­weighing 150±10 g. Inter­ven­tions: Ani­mals ­were ran­domly ­assigned to one of the 4 fol­lowing ­groups: the con­trol ­group, the 1-­week-exer­cise ­group, the 4-­week-exer­cise ­group, and the 8-­week-exer­cise ­group. Meas­ures: Lym­pho­cyte ­subset frac­tions, ­including ­those for T, B, CD4+, and CD8+ ­cells and the T/B and CD4+/CD8+ ­ratios in the periph­eral ­blood and ­spleen ­were meas­ured via ­flow cyto­metric anal­ysis ­after tread­mill exer­cise.
­Results. The T ­cell and CD4+ ­cell frac­tions in ­both the periph­eral ­blood and ­spleen ­were ­increased sig­nif­i­cantly ­after 8 ­weeks of tread­mill exer­cise, but the B ­cell and CD8+ ­cell frac­tions did not ­change sig­nif­i­cantly.
Con­clu­sion. ­From the ­results of the ­present ­study, it is sug­gested ­that a ­period of one ­week is insuf­fi­cient to elim­i­nate the ­effects of exer­cise-­induced ­stress, ­that 4 ­weeks are ­needed to ­return to the con­trol ­state, and ­that at ­least 8 ­weeks are ­needed in ­order for exer­cise of mod­erate inten­sity to ­have a pos­i­tive ­effect on the ­immune ­system.

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