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ULTIMO FASCICOLOTHE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Rivista di Medicina, Traumatologia e Psicologia dello Sport


Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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The Journal of Sports Medicine and Physical Fitness 1999 Dicembre;39(4):282-4

 ORIGINAL ARTICLES

Resting ser­um anti­ox­i­dant stat­us is pos­i­tive­ly cor­re­lat­ed with ­peak oxy­gen uptake in endu­rance ­trained run­ners

Child R. B., Wilkinson D. M., Fallowfield J. L.

Exercise Physiology Research Group, Centre for Sport Sciences, University College Chichester, College Lane, Chichester, UK

Background. This ­study test­ed the hypoth­e­sis ­that the abil­ity to scav­enge ­free rad­i­cals in ser­um was com­pro­mised in ­trained run­ners.
Methods. Experimental ­design: peak V.O2, the abil­ity to scav­enge ­free rad­i­cals in ser­um and the plas­ma con­cen­tra­tion of mal­on­di­al­de­hyde (MDA) ­were ­assessed in 18 ­male run­ners. Participants: subject char­ac­ter­is­tics (­mean±SEM) ­were ­height 1.77±0.01 m, ­mass 71.4±1.2 kg, age 31±1 ­years and week­ly train­ing dis­tance 45±5 km.­week-1. Measures: venous ­blood sam­ples ­were col­lect­ed at ­rest. Serum ­total anti­ox­i­dant capac­ity (TAC) was deter­mined ­using a chem­ilu­mi­nes­cent tech­nique. This ­involved the oxi­da­tion of lumi­nol, in a reac­tion cat­a­lysed by horse­rad­ish per­ox­i­dase. Serum anti­ox­i­dant pro­tec­tion was quan­ti­fied rel­a­tive to a sol­u­ble vita­min E ana­logue (Trolox) and ­expressed as Trolox equiv­a­lents (Trolox Eq.). MDA was deter­mined ­using a high­ly spe­cif­ic ­assay, ­using ­HPLC ­with flu­o­ri­met­ric detec­tion. Peak V.O2 was deter­mined from expired gas measurements collected during an incremental running test on a motorised treadmill. Data ­were ana­lysed ­using Pearson cor­re­la­tions.
Results. Serum TAC was 500±26 µmol Trolox Eq.l-1, ­with
a plas­ma MDA con­cen­tra­tion of 1.5±0.1 ­mmol.l-1 and
ser­um ­urate con­cen­tra­tion of 274±12 ­mmol.l-1. Peak V.O2 was 63±1 ml.kg-1.min-1. Significant cor­re­la­tions ­were ­observed ­between ­peak V.O2 and ser­um TAC (r=0.365, p<0.05); ­peak V.O2 and ser­um ­urate (r=0.463, p<0.05) and ser­um ­urate and ser­um TAC (r=0.807, p<0.001). Plasma MDA and ser­um TAC ­were not sig­nif­i­cant­ly cor­re­lat­ed (r=0.026, p>0.05).
Conclusions. These ­data dem­on­strate ­that the abil­ity to ­quench ­free rad­i­cals in ser­um is ­increased in rela­tion to the max­i­mum abil­ity to con­sume oxy­gen, how­ev­er ­this ­response ­does not ­appear to pro­vide any addi­tion­al pro­tec­tion ­against per­ox­i­da­tive dam­age ­at rest.

lingua: Inglese


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