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Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Lee E. G. 1, Fox M. E. 1, Meadows G. G. 2, Johnson E. C. 1, Blank S. E. 1
1 Department of Kinesiology and Leisure Studies, Washington State University, Pullman, WA, USA;
2 Department of Pharmaceutical Sciences, Washington State University, Pullman, WA, USA
Background. This study was designed to examine the relationship between endurance training volume and natural killer cell (NK) cytolytic activity. We hypothesized that a dose dependent relationship exists between forced treadmill training volume and training induced increases in NK cell cytolytic activity.
Methods. Experimental design: female, Swiss Webster mice were assigned to treadmill control (TC) or treadmill trained groups (n=10 per group). Trained mice ran at 12 m per min. (8˚ grade) for: 15 (EX15), 30 (EX30), or 60 minutes (EX60) per day, five days per week for 11 weeks. Splenic NK cell activity was expressed as median lytic unit (LU), median LU per asialo GM1 (AsGM1+) cell, and median LU per spleen.
Results. Median NK activity was not significantly increased by training volume. A trend toward greater median LU per AsGM1+ cell was observed in EX30 group versus TC (p=0.1). Training volumes less than or greater than this level produced smaller increases in NK cytolytic activity.
Conclusions. These data provide preliminary evidence indicating that training induced increases in splenic NK cell cytolytic activity do not exhibit a dose dependent relationship with treadmill training volume.