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ULTIMO FASCICOLOTHE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Rivista di Medicina, Traumatologia e Psicologia dello Sport

Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111

Periodicità: Mensile

ISSN 0022-4707

Online ISSN 1827-1928

 

The Journal of Sports Medicine and Physical Fitness 1999 Giugno;39(2):140-6

 ORIGINAL ARTICLES

Can reti­cu­lo­cyte param­e­ters be of use in detect­ing ­iron defi­cient eryth­ro­poie­sis in ­female ath­letes?

Ashenden M. J. 2, Pyne D. B. 1, Parisotto R. 1, Dobson G. P. 2, Hahn A. G. 1

1 Department of Physiology and Applied Nutrition, Australian Institute of Sport, Canberra;
2 Department of Physiology and Pharmacology, James Cook, University of Nth Qld., Townsville, Australia

Background. The pur­pose of ­this ­study was to inves­ti­gate wheth­er mon­i­tor­ing reti­cu­lo­cyte pro­files, ­which are ­known to ­respond to ­iron ­store deple­tion in sed­en­tary pop­u­la­tions, ­could ­also be util­ised ­with intense­ly train­ing ath­letes.
Methods. A ret­ro­spec­tive ­study of ­blood sam­ples ­from 134 nation­al lev­el ath­letes (61 ­males, 73 ­females) at the Australian Institute of Sport ­were ana­lysed, ­from ­which ref­er­ence rang­es ­were cal­cu­lat­ed. To ascer­tain the stabil­ity of reti­cu­lo­cyte pro­files dur­ing peri­ods of ­intense phys­i­cal train­ing, the ­intra-indi­vid­u­al vari­a­tion of ­these param­e­ters in 12 ­iron-­replete ­female ath­letes ­over a ­four ­month peri­od of train­ing was doc­u­ment­ed. The pre­ci­sion ­with ­which the ana­lyz­er meas­ured ­these param­e­ters was ­also deter­mined ­using dupli­cate sam­ples ­from 37 ­female ath­letes. To estab­lish wheth­er reti­cu­lo­cyte param­e­ters ­were sen­si­tive to ­iron defi­cient eryth­ro­poie­sis in ath­letes, reti­cu­lo­cyte pro­files of ­five ­female ath­letes diag­nosed by med­i­cal per­son­nel as hav­ing deplet­ed ­iron ­stores ­were com­pared ­before and ­after ­iron ther­a­py to sev­en con­trols.
Results. Corpuscular hemo­glo­bin con­cen­tra­tion ­mean (CHCMr) and ­mean cor­pus­cu­lar vol­ume (MCVr) ­showed lit­tle vari­a­tion ­over ­time in ­iron-­replete ­females, ­with 95% of all fluc­tu­a­tions ­being with­in 5.8% and 4.3% of orig­i­nal val­ues, respec­tive­ly. Iron sup­ple­men­ta­tion in ath­letes ­with deplet­ed ­iron ­stores elic­it­ed an ­increase in CHCMr (p=0.01), and a ­decrease in the dis­tri­bu­tions of reti­cu­lo­cyte vol­ume (RDWr, p=0.01) and ­cell hemo­glo­bin con­cen­tra­tion (HDWr, p<0.01). The ­ratios of reti­cu­lo­cyte to ­mature ­cell MCV (p<0.01) and ­CHCM (p<0.01) ­also ­changed fol­low­ing ­iron ther­a­py. No ­such chang­es ­occurred in non-sup­ple­ment­ed con­trols ­with nor­mal ­iron ­stores.
Conclusions. These ­data ­lend sup­port to the the­sis ­that mon­i­tor­ing of reti­cu­lo­cyte param­e­ters can be of use in detect­ing ­iron defi­cient eryth­ro­poie­sis in ­female ath­letes.

lingua: Inglese


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