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Panminerva Medica 2016 December;58(4): 341-8

lingua: Inglese

The MDM2 T309G polymorphism and risk of lung cancer: an updated meta-analysis of 10,186 cases and 14,155 controls

Xiaodong TIAN, Bo WANG, Juntang GUO, Xi LIU, Tao ZHANG, Chaoyang LIANG, Naikang ZHOU, Xiaobin HOU, Yongfu MA, Hua YU, Lei CHEN, Zhipeng REN, Kaijie FAN, Qing TIAN

Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China


INTRODUCTION: The aim of this paper was to assess the relationship between MDM2 (mouse double minute 2 homolog) T309G polymorphism and the risk and prognosis of lung cancer.
EVIDENCE ACQUISITION: We did a systematic review of relevant articles from EBSCO, EMBASE, Web of science, PubMed, springer link, science direct, weipu database and CNKI (Chinese National Knowledge Infrastructure) databases up to January 7, 2016.
EVIDENCE SYNTHESIS: Seventeen case-control studies and 5 cases prognosis were included. The results indicated that the MDM2 T309G polymorphism was associated with lung cancer risk. Subgroup analysis by ethnicity also showed that associations are significant in Asian. Five prognosis studies were also included. Patients with TT genotype had a higher survival rate at 20-months-follow-up compared with those who carried TG or GG genotype (TT vs. TG+GG: OR=0.34, 95% CI: 0.12-0.99, P<0.05).
CONCLUSIONS: MDM2 T309G polymorphism is associated with risk and prognosis of lung cancer. TT or T genotype may be associated with the reduced risk of lung cancer, especially in Asians. Meanwhile, TT genotype is also associated with the improved prognosis of the lung cancer.

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