Home > Riviste > Panminerva Medica > Fascicoli precedenti > Panminerva Medica 2015 December;57(4) > Panminerva Medica 2015 December;57(4):201-9

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

PANMINERVA MEDICA

Rivista di Medicina Interna


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,698


eTOC

 

REVIEWS  FREEfree


Panminerva Medica 2015 December;57(4):201-9

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

MicroRNAs in HBV-related hepatocellular carcinoma: functions and potential clinical applications

Petrini E. 1, Caviglia G. P. 2, Abate M. L. 2, Fagoonee S. 3, Smedile A. 1, 2, Pellicano R. 1

1 Department of Gastroenterology and Hepatology, Città della Salute e della Scienza, Molinette Hospital, Turin, Italy; 2 Department of Medical Sciences, University of Turin, Turin, Italy; 3 Institute for Biostructures and Bioimages-CNR, c/o Molecular Biotechnology Center, University of Turin, Turin, Italy


FULL TEXT  


Hepatitis B virus (HBV) infection is still a relevant problem worldwide and many cases of hepatocellular carcinoma (HCC) are related to HBV. The prognosis of HBV-related HCC is poor, particularly for advanced stage diagnosis. Although follow-up strategies were adopted for patients at risk, there is need for an optimal early biomarker for the screening purpose. MicroRNAs (miRNAs) are small non-coding RNAs, tightly connected to cell type and differentiation status and act as genetic regulator which can be involved in oncogenic processes. The alteration in miRNA expression pattern may represent a new opportunity for HBV-related HCC diagnosis and therapies. Some studies focused on miRNA polymorphism responsible for HCC susceptibility; others found several miRNAs deregulated by HBV X protein as well as miRNAs altered in HBV-related HCC tissue and cells. A high variability among results emerged, probably due to different techniques employed, biological substrates, experimental procedures, criteria of miRNAs selection and ethnic provenience of the included patients. Interestingly, circulating miRNAs have been studied as potential HCC-biomarkers but the reported accuracy is still not convincing, particularly in distinguishing patients with HCC from patients with cirrhosis. Hence, the use of miRNAs remains in an experimental phase and more studies are required to define their role in the clinical practice.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail

caviglia.giampi@libero.it