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Rivista di Medicina Interna
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2013 Settembre;55(3):297-302
Optimal conditions for “heat-conduct effect” in liver tissue during radiofrequency ablation
Jiang K., Su M., Liu Y., Zhao X., Liu J., Zhang W., Wang J., Dong J., Huang Z. ✉
Institute and Hospital of Hepatobiliary Surgery Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA Chinese PLA Medical School Chinese PLA General Hospital, Beijing, China
Aim: This study was conducted to optimize the “heat-conduct effect” to increase the efficacy of radiofrequency ablation (RFA) in the treatment of liver tumors.
Methods: To simulate the “heat-conduct effect” caused by RFA, isolated pig livers were heated by an inserted metal tube through which water with different incoming temperatures was passed. The tissue temperature was measured within 5- and 10-mm radiuses. Further, changes in color and morphology of the tissue were recorded.
Results: Using an incoming temperature of 70 °C, the effective ablation radius of 5 mm was achieved within 10 min. To expand the effective radius to 10 mm, the tube temperature needed to be maintained at above 80 °C for 40 min; alternatively, the tube temperature above 90 °C and heating time of 25 min were also sufficient.
Conclusion: To achieve the complete ablation in isolated liver within the 10 mm radius by “heat-conduct effect”, the temperature of the heating center should be maintained above 80 – 90 °C with the exposure time of 25-40 min.