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Panminerva Medica 2011 September;53(3):193-202

lingua: Inglese

Helicobacter pylori and ischemic heart disease

Vizzardi E. 1, Bonadei I. 1, Piovanelli B. 1, Quinzani F. 1, Ricci C. 2, Lanzini A. 2, Dei Cas L. 1

1 Department of Cardiology, University of Brescia, Brescia, Italy
2 Department of Gastroenterology, University of Brescia, Brescia, Italy


In the last years, a considerable number of studies have been performed on the relationship between infection from Helicobacter Pylori and atherosclerotic diseases, like stroke and ischemic heart disease. In particular, some infections could have a role on the genesis and development of damage to the vascular wall and of atheromatous plaque. It has been suggested that HP could influence the development of IHD through different pathways, such as endothelial cells colonization, changes in the lipid profiles, increased coagulation and platelet aggregation levels, induction of molecular mimicry mechanisms and the promotion of a low-grade systemic inflammation. Based on this hypothesis, it has been performed a considerable number of studies in order to investigate the role of HP in the development and pathogenesis of CAD. Most of this trials gave conflicting results, some denying the presence of a possible relationship between HP infection and increased risk of CAD. Despite of that, results from these studies have raised new interesting perspectives on coronary heart disease, especially regarding the possibility of modifying the clinical history of the disease through eradication of these microorganisms. The results are contradictory and require further investigation.

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