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Panminerva Medica 2003 Settembre;45(3):197-201

lingua: Inglese

Central and peripheral activities of ghrelin, a ligand of the growth hormone secretagogue receptor

Bona G., Bellone S.

Unit of Pediatrics Department of Medical Sciences “Piemonte Orientale” University, Novara, Italy


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Ghrelin, a 28 ami­no-­acid acy­lat­ed pep­tide pre­dom­i­nant­ly pro­duced by the stom­ach, dis­plays ­strong GH-releas­ing activ­ity medi­at­ed by the hypo­thal­a­mus-pitui­tary GH secretagogues (GHS) recep­tors ­which had ­been ­shown spe­cif­ic for a fam­i­ly of syn­thet­ic, oral­ly ­active GHS. GHS ­also act on cen­tral and periph­er­al recep­tors and ­show oth­er ­actions includ­ing an orex­i­gen­ic ­effect, influ­ence on gas­tro-ente­ro-pan­creat­ic func­tions, car­di­o­vas­cu­lar and ­anti-pro­life­ra­tive ­effects. Ghrelin man­ag­es the neu­ro­en­do­crine and meta­bol­ic ­response to star­va­tion. Taking ­into ­account its orex­i­gen­ic ­effect, GHS ana­logues act­ing as ago­nists or antag­o­nists on appe­tite ­could rep­re­sent new ­drug inter­ven­tion in eat­ing dis­or­ders.

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