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Panminerva Medica 2003 Giugno;45(2):151-4

lingua: Inglese

Pathophysiology of endothelin and medical emergencies

Bruno C. M., Neri S., Di Prima P., Sciacca C.

Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy


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Pathophysiology of endo­the­lin-1, a vas­o­con­stric­tor and a mit­o­gen­ic pep­tide, has ­been exten­sive­ly inves­ti­gat­ed in ­recent ­years. The ­authors ­have exam­ined the ­main clin­i­cal and experi­men­tal evi­denc­e regard­ing the involve­ment of ­this pep­tide in ­some med­i­cal emer­gen­cies, name­ly myo­car­dial infarc­tion, ­stroke and hepa­to-­renal syn­drome. Literature ­data sug­gest an emerg­ing path­o­phy­sio­log­i­cal ­role for endo­the­lin in ­such clin­i­cal con­di­tions.

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