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Panminerva Medica 2003 June;45(2):123-31

lingua: Inglese

Emerging risk factors and assessment of organ damage in postmenopausal hypertensive women

Noto R. 1, Molino G. 1, Sciacchitano G. 2, Noto P. 1, Caschetto S. 2

1 Department of Internal Medicine and Systemic Pathologies, University of Catania, Catania, Italy
2 Department of Obstetrics and Gynecology and Radiological Sciences, University of Catania, Catania, Italy


The numer­ous ­risk fac­tors for ­acute cereb­ro­car­di­o­vas­cu­lar ­events ­present in post­men­o­pau­sal wom­en ­have attract­ed a mul­ti­dis­ci­pli­nary ­approach. In hyper­ten­sive ­patients and post­men­o­pau­sal inten­sive ­alike, the ­need for strat­ifi­ca­tion of ­risk ­based on ­blood pres­sure, asso­ci­a­tion of oth­er ­risk fac­tors and ­organ dam­age is becom­ing ­more and ­more evi­dent. This ­study inves­ti­gat­ed ­some emerg­ing fac­tors, ­such as endo­the­lial dys­func­tion, adhe­sion mole­cules and ele­vat­ed homo­cys­teine lev­els ­that may be mark­ers of ­organ dam­age. It ­also exam­ined the cur­rent impor­tance of carot­id US inti­ma-­media thick­ness assess­ment, car­diac US imag­ing and 24 ­hour ­ambulatory blood pressure monitoring (ABPM) in detect­ing ­organ dam­age. The ­study ­results indi­cat­ed ­that the con­ven­tion­al strat­ifi­ca­tion of cereb­ro­car­di­o­vas­cu­lar ­risk in ­these ­patients is chang­ing. The new ­approach in post­men­o­pau­sal hyper­ten­sives ­tends to ­assess the pres­ence of oth­er emerg­ing fac­tors. Furthermore, assess­ment of ­organ dam­age is cru­cial for deter­min­ing dis­ease devel­op­ment and out­come ­that may be pos­i­tive­ly influ­enced by suit­able phar­mac­o­log­i­cal treat­ment.

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