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Panminerva Medica 2002 December;44(4):369-71

lingua: Inglese

p53 and Ki-67 expression in epithelial gastric dysplasia and in gastric cancer

Testino G. 1, Gada D. 2, De Iaco F. 3, Cornaggia M. 2

1 Unit of Hepato-Gastroenterology S. Martino Hospital, Genoa, Italy
2 Department of Human Pathology University of Insubria, Varese, Italy
3 Unit of Internal Medicine Bordighera Hospital, Bordighera, Italy


Background. The aim of ­this ­study was to exam­ine p53 and Ki-67 expres­sion in rela­tion to ­high ­grade dys­pla­sia (HGD) clin­i­cal beha­vi­our.
Methods. A ret­ro­spec­tive, ­cross sec­tion­al ­study was con­duct­ed on muco­sal biop­sies ­from the stom­ach of 38 con­sec­u­tive cas­es of ­HGD (25 ­males, aver­age age: 57.5). The stud­ied sam­ples are rep­re­sent­ed by gas­tric biop­sies ­obtained in ­course of gas­tros­co­py for dys­pep­sia (at ­least 8 biop­sies). HGD diag­no­sis was ­done by expe­ri­enced pathol­o­gists (MC, DG) accord­ing to Goldstein’s cri­te­ria. There ­were 12 non-dys­plas­tic con­trols (7 ­males, aver­age age: 49.4). The immu­no­his­to­chem­i­cal ­study has ­been led ­with the util­iza­tion of a p53-anti­body. For the ­cell pro­life­ra­tion ­assay, the sec­tions ­were incu­bat­ed ­with the MM1 mono­clo­nal anti­body. The clin­i­cal out­come sub­di­vi­sion of HGD was effect­ed ­using the cri­te­ria of Rugge et al. For the clas­sifi­ca­tion of gas­tric can­cer (GC): ­UICC TNM.
Results. p53 pos­i­tiv­ity has ­been evi­denced in 65.5% of cas­es, ­while hyper­pro­lif­er­a­tion in 100% of cas­es. That inde­pen­dent­ly of the clin­i­cal beha­vi­our.
Conclusions. p53 pos­i­tiv­ity has ­been ­found ­only in ­part of the HGD cas­es and more­over a num­ber of HGD ­with low or ­absent p53 ­scores has ­been ­found asso­ciat­ed ­with ­high pro­life­ra­tion indi­ces inde­pen­dent­ly of the clin­i­cal evo­lu­tion. This dis­so­ci­a­tion of ­cell kinet­ics and p53 expres­sion sug­gests ­that oth­er genet­ic ­events con­trib­ut­ing to unreg­u­late ­cell pro­life­ra­tion may ­occour in ­these ­lesions.

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