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Panminerva Medica 2002 December;44(4):353-7

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Immune status and autoantibody formation in children with chronic hepatitis B infection

Unal F., Genel F., Ozgenc F., Aksu G., Aydogdu S., Kutukculer N., Yagci R. V.

Department of Pediatric Immunology and Pediatric Gastroenterology, Ege University Faculty of Medicine, Izmir, Turkey


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Background. The hep­a­titis B ­virus (HBV) caus­es a ­wide spec­trum of dis­ease ­which rang­es ­from ­acute hep­a­titis to liv­er cir­rho­sis. Patients who ­fail to ­mount a vig­or­ous ­immune ­response in ­acute HBV devel­op chron­ic infec­tion. Therefore, the aim of the ­study was to deter­mine the cel­lu­lar and humo­ral ­immune param­e­ters of the ­patients ­with chron­ic HBV and to eval­u­ate the prev­a­lence of auto­an­ti­bod­ies ­before the begin­ning of immu­no­mod­u­la­tor and anti­vi­ral ther­a­py.
Methods. In ­this com­par­a­tive ­study, ser­um immu­no­glob­u­lins, IgG sub­class­es, secre­to­ry IgA, ser­um com­ple­ment com­po­nents, lym­pho­cyte sub­sets and CD11a, CD18, CD54 mole­cules on lym­pho­cytes ­were deter­mined in 44 hos­pi­tal­ized ­patients of chron­ic HBV infec­tion and 20 cas­es of ­healthy con­trol sub­jects.
Results. Significant ­increase in IgG and sig­nif­i­cant ­decrease in the com­ple­ment C4 ­were ­observed. The ­mean per­cent­age of CD3+ lym­pho­cytes, reflect­ing the per­cent­age of ­total T ­cells was sig­nif­i­cant­ly high­er in the ­patient ­group due to the ­increase of CD8+ lym­pho­cytes. The ­mean per­cent­age of CD19+ B lym­pho­cytes was low­er in the ­patient ­group sec­on­dary to the ­increase of ­their ­total T ­cells. No sig­nif­i­cant dif­fer­ence was ­found in ­cell sur­face adhe­sion mole­cules ­between ­patient and con­trol ­groups. The per­cent­age of anti­nu­cle­ar anti­body pos­i­tiv­ity was 18.2%.
Conclusions. Our ­data ­show ­that ANA for­ma­tion is ­part of the nat­u­ral ­course of chron­ic HBV infec­tion and ­this val­ue may ­reflect the ten­den­cy to auto­im­mune dis­eas­es and the impor­tance of clin­i­cal fol­low-up. The abnor­mal­ities ­observed in immu­no­log­i­cal param­e­ters may ­reflect the ­role of the cel­lu­lar and humo­ral ­immune ­system in path­o­gen­e­sis.

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