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Panminerva Medica 2002 December;44(4):325-33

lingua: Inglese

Neurotrophins and the control of axonal outgrowth

Tucker K. L.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland


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The neu­ro­troph­ins NGF, ­BDNF, NT-3, and NT-4/5 are ­well ­known for ­their neu­ron sur­vi­val-pro­mot­ing func­tions. This ­review focus­es ­upon a ­less-inves­ti­gat­ed func­tion of ­this ­gene fam­i­ly, name­ly ­that of con­trol­ling the ­growth of ­axons in ­vivo. Recent evi­dence is dis­cussed ­that ­reveals a defin­i­tive require­ment for neu­ro­tro­phin sig­nal­ing in the elon­ga­tion of periph­er­al ­nerves dur­ing embryon­ic devel­op­ment.

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