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Rivista di Medicina Interna

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Periodicità: Trimestrale

ISSN 0031-0808

Online ISSN 1827-1898


Panminerva Medica 2002 Settembre;44(3):243-51


Phosphate measurements during hypokinesia and phosphate supplements in disclosing phosphate changes in hypokinetic subjects

Zorbas Y. G., Kakurin V. J., Kuznetsov N. A., Yarullin V. L., Andreyev I. D. *, Charapakhin K. P. *

Higher Institute of Biochemistry, Gomel, Belarus
*European Foundation of Environmental Sciences Athens, Greece

Background. Hypokinesia (dimin­ished move­ment) ­induces sig­nif­i­cant phos­phate (P) ­change, how­ever, ­little is ­known ­about P reten­tion and P deple­tion ­during hypo­ki­nesia (HK). Measuring P reten­tion and P bal­ance ­during HK and P sup­ple­men­ta­tion, the objec­tive of ­this ­work was to dis­close ­whether HK ­could con­tribute to the ­decreased P reten­tion and con­se­quently to P deple­tion in ­normal sub­jects.
Methods. Studies ­were ­done ­during 30 ­days pre-HK ­period and 364 ­days HK ­period. Forty ­normal ­male indi­vid­uals ­aged, 25.3±6.4 ­years ­were ­chosen as sub­jects. They ­were ­divided ­equally ­into 4 ­groups: unsup­ple­mented ­active con­trol sub­jects (­UACS), unsup­ple­mented hypo­ki­netic sub­jects (­UHKS), sup­ple­mented ­active con­trol sub­jects (­SACS) and sup­ple­mented hypo­ki­netic sub­jects (­SHKS). Hypokinetic sub­jects ­were lim­ited to an ­average ­walking dis­tance of 0.5 km·day-l, ­while ­active con­trol sub­jects ­were ­kept on an ­average run­ning dis­tance of 9.6 km·day-l. Both, ­SHKS and ­SACS ­received ­daily 14 ­mmol dical­cium phos­phate per kg ­body ­weight.
Results. Negative P bal­ance, ­fecal P, uri­nary cal­cium (Ca) and P excre­tion, ­serum P and ­total (Cat) ­level ­increased sig­nif­i­cantly (p<0.05) ­while P reten­tion, ­serum ­intact para­thy­roid hor­mone (iPTH), 1,25 dihy­drox­y­vit­amin D (1,25 (OH)2 D3) and thy­ro­cal­cit­onin (TC) ­decreased sig­nif­i­cantly (p<0.05) in ­SHKS and ­UHKS com­pared ­with ­their pre-HK ­values and ­their respec­tive ­active con­trols (­SACS and ­UACS). However, neg­a­tive P bal­ance, P reten­tion inca­pacity, ­serum, ­fecal and uri­nary P ­level ­increased sig­nif­i­cantly (p<0.05) ­more in ­SHKS com­pared ­with ­UHKS. Fecal P ­loss, uri­nary P and Ca ­loss, ­serum P and Cat ­level, iPTH, TC and 1,25 (OH)2 D3 ­level, P reten­tion and P bal­ance ­change insig­nif­i­cantly (p>0.05) in ­SACS and ­UACS com­pared ­with ­their pre-HK ­level.
Conclusions. It was con­cluded ­that a sig­nif­i­cant P excre­tion in ­urine and ­feces in ­spite of neg­a­tive P bal­ance and P sup­ple­men­ta­tion may dem­on­strate ­reduced P reten­tion, ­while a sig­nif­i­cant ­increase of neg­a­tive P bal­ance may dem­on­strate P deple­tion. Clearly, P ­intake, regard­less of its low or ­higher ­dose, was sig­nif­i­cantly ­wasted ­during HK prob­ably due to the ­decreased ­ability of the ­body to ­retain P.

lingua: Inglese


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