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Panminerva Medica 2002 March;44(1):19-22

lingua: Inglese

Helicobacter pylori influence on gastric acid secretion in duodenal ulcer patients diagnosed for the first time

Testino G., Cornaggia M. *, De Iaco F. **

From the Unit of Gastroenterology, S. Martino Hospital, Genova, Italy
*Department of Human Pathology, University of Pavia, Varese, Italy
**Internal Medicine, Bordighera Hospital, Italy


Background. Many expe­ri­enc­es ­have hypo­the­sised ­that Helicobacter pylo­ri ­induced hyper­gas­tri­ne­mia ­could ­lead to an ­increase of the parie­tal ­cell ­mass and, con­se­quent­ly, of ­acid secre­tion.
Methods. The parie­tal ­cell ­mass and max­i­mal ­acid out­put ­have ­been stud­ied in ­patients ­with duod­en­al ­ulcer diag­nosed for the ­first ­time, not due to ­drugs assump­tion. In par­tic­u­lar, it has ­been eval­u­at­ed the parie­tal ­cell ­mass and the ­acid secre­tion sub­di­vid­ing duod­en­al ­ulcer ­patients in rela­tion to gas­tri­ne­mia val­ues (hyper­gas­tri­ne­mia and nor­mo­gas­tri­ne­mia).
Results. The parie­tal ­cell ­mass and the max­i­mal ­acid out­put ­remain ­high inde­pen­dent­ly of Helicobacter pylo­ri pres­ence. About 60% of the sub­jects in the Helicobacter pylo­ri pos­i­tive ­group ­show gas­tri­ne­mia val­ues high­er ­than the aver­age: nei­ther did the ­study ­reveal in ­this ­group any vari­a­tions in the parie­tal ­cell ­mass and ­acid secre­tion.
Conclusions. It emerg­es ­from the ­results ­that the ­mild chron­ic hyper­gas­tri­ne­mia in Helicobacter pylo­ri pos­i­tive duod­en­al ­ulcer is not impor­tant ­enough to ­induce an ­increase in parie­tal ­cell ­mass and ­acid secre­tion. Therefore, Helicobacter pylo­ri erad­i­ca­tion is impor­tant in ­relapse pre­ven­tion of duod­en­al ­ulcer, but not for its reper­cus­sions on the gas­tric secre­tion.

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