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Panminerva Medica 2002 March;44(1):3-6

lingua: Inglese

Scintigraphy with 99mTc-MIBI and echography in the study of primitive hyperparathyroidism

Falvo L., D’Andrea V., D’Ercole C., Grilli P., Catania A., Sorrenti S., Berni A., De Antoni E.

From the Division of General Surgery Department of Surgical Sciences University of Rome “La Sapienza”, Rome, Italy


Background. The ­authors ana­lyse the val­ue of the ­exames pre­op­er­a­tive for the iden­tifi­ca­tion of the path­o­log­i­cal para­thy­roid ­glands.
Methods. The ­authors exam­inat­ed 58 ­patients affect­ed by prim­i­tive hyer­pa­rath­yr­oi­dism (HPTp) who had under­gone sur­gi­cal treat­ment for pri­mary hyper­pa­rath­yr­oi­dism at the Third Surgical Department of University “La Sapienza” of Rome, in 175 ­patients affect­ed by prim­i­tive hyper­pa­rath­yr­oi­dism ­observed ­between January 1970 and June 2000; all ­patients had under­gone echot­o­mog­ra­phy of the ­neck and 99mTc-­MIBI scin­tig­ra­phy in the diag­nos­tic ­phase. The his­to­log­i­cal val­u­a­tion con­firmed the diag­no­sis by I.P.
Results. 99mTc-­MIBI scin­tig­ra­phy demons­trated the path­o­log­i­cal ­glands in 56 cas­es (96.6%), the echog­ra­phy in 57 cas­es (98.2%). The com­pa­ri­son of the two ­exams demons­trated the path­o­log­i­cal ­glands in 100% of the cas­es. In 45 cas­es the scin­tig­ra­phy localized the ­side (77.6%), and the echog­ra­phy in 41 cas­es (70.7%). In one ­case dem­on­strat­ed I.P. per­sis­tent (1.7%) and never­ one ­case demon­strated ­relapsed.
Conclusions. The ­authors ­think ­that the scin­tig­ra­phy togh­ether with the echog­ra­phy ­show high sen­sibil­ity to iden­tifi­ca­tion the path­o­log­i­cal ­glands. Neck sur­gi­cal explo­ra­tion can ­still ­give the ­side ­good ­when the diam­e­ter of the par­a­thyr­oids is infe­ri­or to 5 mm.

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