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Panminerva Medica 2001 June;43(2):115-8

lingua: Inglese

Sexually and well-being in early menopause. Effect of transdermal estradiol therapy

Rigano A. *, Rigano M. **, Cancellieri F. **, Pullè C. **

From the Department of Obstestric and Gynecology
*Endocrinological Gynecolocy
**Gynecologic and Obstetric Clinic University of Messina, Messina, Italy


Background. This ­study ­focus on the ­effect of 6 ­months trans­der­mal estrad­i­ol ther­a­py (TTS) on the sex­u­al beha­vi­our and the qual­ity of ­life in ear­ly men­o­pau­sal wom­en, com­plain­ing of uncom­fort­able men­o­pau­sal symp­toms.
Methods. Three hundred and sixty-two post­men­o­pau­sal wom­en, ­aged 48-56, par­tic­i­pat­ed in ­this ­study. One hundred and seventy-one of ­them ­were giv­en con­tin­u­ous sol­id ­matrix ­patch TTS 50 μg/day for 6 ­months. Sexual beha­vi­our, men­o­pau­sal symp­toms and ­well-­being ­were eval­u­at­ed ­through a ­self-rat­ing meth­od. We ­used a struc­tured ques­tion­naire ­with ­three oblig­a­to­ry ­answers (­less/­same/­more) for ­each ques­tion—sex­u­al ­life, hot flush­es, touchi­ness, insom­nia, ­blood pres­sure, ­work will­ing, mem­o­ry ­loss, ­well-­being—, ­filled in by the wom­en them­selves or by the med­i­cal ­equipe ­after a tele­phone inter­view.
Results. Seventy five per cent of wom­en ­aged 51-53 and 84% ­aged 54-56, who had ­been treat­ed for 6 ­months ­with TTS ­showed a ­fall of sex­u­al ­drive, if com­pared ­with, respec­tive­ly, 62% and 48% of untreat­ed sub­jects. Relief of hot flush­es, touchi­ness and insom­nia ­occurred in 80% of treat­ed wom­en, ­with ­slight dif­fer­enc­es ­among the var­i­ous ­groups ­while 61% ­showed ­increase of ­well-being.
Conclusions. The ­results of our ­study dem­on­strate ­that con­tin­u­ous TTS for 6 ­months ­decreased sex­u­al ­drive in 69% of wom­en, ­improved men­o­pau­sal symp­toms in 80% wom­en but ­increased ­well-­being ­only in 61% of wom­en. These dif­fer­enc­es sug­gest ­that ­women’s ­well-­being ­does not ­seem ­linked ­only to the ­relief of men­o­pau­sal symp­toms and the impair­ment of ­their sex­u­al ­life can ­play a neg­a­tive ­role.

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