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Rivista di Medicina Interna
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 2000 September;42(3):187-92
Association of alpha-interferon and acetyl cysteine in patients with chronic C hepatitis
Neri S., Ierna D., Antoci S., Campanile E., D’Amico R. A., Noto R.
From the Institute of Internal and Emergency Medicine University of Catania, Italy
Background. Numerous experimental findings have underlined the relationships between liver damage and production of oxygen-derived free radicals during inflammation. In chronic hepatitis C liver disease this damage may be attributed to altered oxide-reductive balance and glutathione (GSH) depletion. Moreover, it may be linked to chronic inflammation provoked by the replicative activity of the hepatitis C virus and its relationships with immune system cells. Our aim was to assess the effects of combined IFN+NAC treatment to compare the effects of interferon α - n1 associated with N-acetyl cysteine treatment with the results observed using interferon therapy alone.
Methods. Experimental design: prospective randomised study.
Setting: ambulatory and hospitalised care. Patients: 77 selected patients affected by chronic C hepatitis. Interventions: our patients were investigated by laboratory tests (ALT values, RIBA test, HCV-RNA, oxide-reductive balance), liver biopsy and liver US. The recruited subjects were treated with interferon and N-acetyl cysteine or with interferon alone.
Results. Our findings confirmed the presence of oxidative stress in patients with chronic hepatitis C and showed earlier relapse in patients treated with interferon alone. The difference between the results in patients treated with interferon and N-acetyl cysteine and those on interferon alone was significant.
Conclusions. The good results and absence of side effects in patients treated with interferon + N-acetyl cysteine recommend wider use of this association.