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FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOPANMINERVA MEDICA

Rivista di Medicina Interna

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6

Periodicità: Trimestrale

ISSN 0031-0808

Online ISSN 1827-1898

 

Panminerva Medica 2000 Giugno;42(2):97-100

 ORIGINAL ARTICLES

The prevalence of delta virus infection in chronic liver disease in Egyptian children in comparison with some other countries

Morcos M. M., Mikhail T. H., Hanna W. M., Abdel-Fattah S. *, El-Rasad M. M. *, Wassef E. L.

From the National Research Centre, Cairo, Egypt
*Ain Shams University, Cairo, Egypt

Background. Hepatitis Delta Virus (HDV) infec­tion has a ­world-­wide dis­tri­bu­tion. The aim of ­this ­study was to estab­lish its prev­a­lence in Egyptian chil­dren ­with chron­ic liv­er dis­ease, and its ­role in the devel­op­ment and ­progress of hepat­ic ill­ness.
Methods. A pros­pec­tive ­study of 45 Egyptian chil­dren who had liv­er cir­rho­sis (n=24) or chron­ic hep­a­titis (n=21) was ­done. They ­were con­sec­u­tive­ly cho­sen. Their ­ages ­ranged ­from 2-15 ­years (­median=5). Serological stud­ies ­were per­formed to ­detect the pres­ence of hep­a­titis B sur­face anti­gen (HBs Ag) and HDV infec­tion IgG ­anti­body (IgG ­anti-HD).
Results. Anti-del­ta anti­body (IgG ­anti-HD) was detect­ed in ­only ­four chil­dren ­with hepat­ic cir­rho­sis and non of the chron­ic hep­a­titis, ­with an over­all prev­a­lence of 8.9% (4/45). Three of ­them (75%) ­were hep­a­titis B sur­face anti­gen (HBs Ag) neg­a­tive. Significant sta­tis­ti­cal asso­ci­a­tion ­between del­ta infec­tion and the ­state of hepat­ic ill­ness was detect­ed (p<0.05). Whereas HBs Ag was detect­ed in 54% (13/24) of liv­er cir­rho­sis and 52% (11/21) of chron­ic hep­a­titis , ­with an over­all prev­a­lence of 53% (24/45). There was no sta­tis­ti­cal­ly sig­nif­i­cant asso­ci­a­tion ­between HBs Ag pos­i­tiv­ity and ­state of hepat­ic ill­ness.
Conclusions. The prev­a­lence of HDV infec­tion is 8.9% of Egyptian chil­dren ­with chron­ic liv­er dis­ease. HDV infec­tion in chil­dren is asso­ciat­ed ­with ­advanced chron­ic liv­er dis­ease.

lingua: Inglese


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