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Panminerva Medica 2000 June;42(2):97-100

lingua: Inglese

The prevalence of delta virus infection in chronic liver disease in Egyptian children in comparison with some other countries

Morcos M. M., Mikhail T. H., Hanna W. M., Abdel-Fattah S. *, El-Rasad M. M. *, Wassef E. L.

From the National Research Centre, Cairo, Egypt
*Ain Shams University, Cairo, Egypt


Background. Hepatitis Delta Virus (HDV) infec­tion has a ­world-­wide dis­tri­bu­tion. The aim of ­this ­study was to estab­lish its prev­a­lence in Egyptian chil­dren ­with chron­ic liv­er dis­ease, and its ­role in the devel­op­ment and ­progress of hepat­ic ill­ness.
Methods. A pros­pec­tive ­study of 45 Egyptian chil­dren who had liv­er cir­rho­sis (n=24) or chron­ic hep­a­titis (n=21) was ­done. They ­were con­sec­u­tive­ly cho­sen. Their ­ages ­ranged ­from 2-15 ­years (­median=5). Serological stud­ies ­were per­formed to ­detect the pres­ence of hep­a­titis B sur­face anti­gen (HBs Ag) and HDV infec­tion IgG ­anti­body (IgG ­anti-HD).
Results. Anti-del­ta anti­body (IgG ­anti-HD) was detect­ed in ­only ­four chil­dren ­with hepat­ic cir­rho­sis and non of the chron­ic hep­a­titis, ­with an over­all prev­a­lence of 8.9% (4/45). Three of ­them (75%) ­were hep­a­titis B sur­face anti­gen (HBs Ag) neg­a­tive. Significant sta­tis­ti­cal asso­ci­a­tion ­between del­ta infec­tion and the ­state of hepat­ic ill­ness was detect­ed (p<0.05). Whereas HBs Ag was detect­ed in 54% (13/24) of liv­er cir­rho­sis and 52% (11/21) of chron­ic hep­a­titis , ­with an over­all prev­a­lence of 53% (24/45). There was no sta­tis­ti­cal­ly sig­nif­i­cant asso­ci­a­tion ­between HBs Ag pos­i­tiv­ity and ­state of hepat­ic ill­ness.
Conclusions. The prev­a­lence of HDV infec­tion is 8.9% of Egyptian chil­dren ­with chron­ic liv­er dis­ease. HDV infec­tion in chil­dren is asso­ciat­ed ­with ­advanced chron­ic liv­er dis­ease.

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