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Panminerva Medica 2000 Marzo;42(1):69-75

lingua: Inglese

Red radioluminescence and radiochemiluminescence: premises for a photodynamic tumour therapy with X-rays and haematoporphyrin derivates. A working hypothesis

Bistolfi F.

Department of Radio­ther­a­py Gal­lie­ra Hos­pi­tal, ­Genoa


In a 1989 ­paper the ­author put for­ward the hypoth­e­sis of homo­ge­ne­ous­ly illu­mi­nat­ing the inter­i­or of the ­human ­body ­with red ­light by ­means of X-­rays, ­with a ­view to extend­ing the pos­sibil­ities of pho­to­dy­nam­ic ther­a­py ­with hae­mat­o­por­phy­rin deriv­a­tives (HPD). In the ­present ­paper, two pos­sible mech­a­nisms for the pro­duc­tion of red ­light by tis­sues irra­di­at­ed ­with X-­rays are put for­ward: a phys­i­cal mech­a­nism (red radio­lu­mi­nes­cence) and a phys­i­cal-chem­i­cal mech­a­nism (red radio­chem­ilu­mi­nes­cence). Reac­tive oxy­gen metab­olites pro­duced in the radiol­y­sis of ­water, sing­let oxy­gen and lip­id per­ox­i­da­tion of bio­mem­branes are the key ­players in ­this inter­est­ing pro­cess. How­ev­er, ­before any clin­i­cal appli­ca­tion can be pro­posed for inte­grat­ed ­tumour ther­a­py (pho­to­dy­nam­ic ther­a­py ­with X-­rays ­instead of ­laser ­light and hae­mat­o­por­phy­rin deriv­a­tives), quan­ti­ta­tive anal­y­ses and experi­men­tal ­research ­will be ­required.

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