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Panminerva Medica 1999 Dicembre;41(4):331-4

lingua: Inglese

Reanimation of the ­heart ­after ­death

Wang N. D., Doty D. B.

From the Grigg Cardiovascular Surgery Laboratory, LDS Hospital, Salt Lake City, Utah, USA


Background. The pur­pose of ­this ­study was to deter­mine if ­hearts ­could be suc­cess­ful­ly rean­i­mated ­after ­death in an ­extra cor­po­real cir­cuit.
Methods. Reanimation of pig and dog ­heart was accom­plished in an ­extra cor­po­real cir­cuit ­after ­death by ­lethal injec­tion of Pentothal (eutha­na­sia). A ­total of 42 experi­ments ­were per­formed.
Results. The ­most suc­cess­ful com­bi­na­tion includ­ed enhance­ment of the car­di­o­pleg­ic and reper­fu­sion solu­tions ­with ami­no ­acids, cal­cium and mag­ne­sium ­ions, and ­using the ani­mals own ­drug ­free ­blood in the reper­fu­sion solu­tion. Successful resus­ci­ta­tion of the ­heart was accom­plished ­after ischem­ic ­cold stor­age as ­long as 9 ­hours ­after ­death. A beat­ing ­heart was sus­tained by the ­extra cor­po­real cir­cuit for ­over 10 ­hours (635 min­utes).
Conclusions. In sum­mary, suc­cess­ful­ly rean­i­ma­tion of the ­heart in an ­extra cor­po­real cir­cuit is pos­sible ­when ­cold car­di­o­pleg­ic solu­tion is admin­is­tered 10-35 min­utes ­after ­death by ­lethal injec­tion of Pentothal.

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