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Panminerva Medica 1999 December;41(4):307-9

lingua: Inglese

Nitrite plas­ma lev­els in nor­mol­i­pem­ic and hyper­chol­es­ter­o­lem­ic ­patients with periph­er­al occlu­sive arter­i­op­a­thy

Ferlito S., Gallina M., Catassi S.*, Bisicchia A.*, Di Salvo M. M.*

From the ­Chair of Semeio­lo­gy and Med­i­cal Meth­o­dol­o­gy Uni­ver­sity of Cata­nia, Ita­ly
* Depart­ment of Angi­ol­o­gy Fer­ra­rot­to Hos­pi­tal, Cata­nia, Ita­ly


Back­ground. The ­authors stud­ied the ­nitrite plas­ma lev­els in a ­group of ­patients ­with periph­er­al obstruc­tive arter­i­op­a­thy.
Meth­ods. The ­series con­sist­ed of 63 sub­jects (43 ­males, 20 ­females, ­mean age 64±9 ­years) suf­fer­ing ­from periph­er­al arte­ri­al occlu­sive dis­ease of the low­er ­limbs, at II (55 cas­es) and III (8 cas­es) Fon­taine ­stage; 21 sub­jects ­with ­total cho­les­te­rol (TC) low­er ­than 200 mg/dl ­were con­sid­ered as nor­mol­i­pem­ics, 24 sub­jects ­with TC val­ues ­between 200 and 240 as ­mild hyper­chol­es­ter­o­lem­ics, 18 sub­jects ­with TC ­above 240 mg/dl as ­severe hyper­chol­es­ter­o­lem­ics. For ­each sub­ject the deter­mi­na­tion of ­nitrite plas­ma lev­els was car­ried out, by the Gut­man and Hol­ly­wood color­imet­ric meth­od.
­Results. In the nor­mol­i­pem­ic arte­ri­o­path­ics the ­basal val­ue of ­nitrites was sharp­ly ­reduced (p<0.05) com­pared to the con­trols; in the ­mild hyper­chol­es­ter­o­lem­ics the ­mean ­basal val­ue of ­nitrites was mark­ed­ly high­er com­pared to the con­trols; in the ­severe hyper­chol­es­ter­o­lem­ics the ­mean ­basal val­ue of ­nitrites was sta­tis­ti­cal­ly (p<0.05) high­er ­than ­that of the con­trols. In the arte­ri­o­path­ic ­patients, glo­bal­ly con­sid­ered, the ­mean ­basal val­ue of ­nitrites was super­im­pos­able on ­that of the nor­mal con­trol sub­jects.
Con­clu­sions. ­This ­study, car­ried out on the ­nitrite plas­ma lev­els in a ­group of arte­ri­o­path­ic ­patients ­allowed us to ­show the ­enhanced lev­els of ­nitric ­oxide due to the ­increase of LDL; ­this ­effect, pre­vi­ous­ly ­observed in hyper­chol­es­ter­o­lem­ic dia­bet­ic and cor­o­nar­o­path­ic ­patients, leads us to the hypoth­e­sis of a stim­u­lat­ing ­effect of LDL ­upon NO endo­the­lial syn­the­sis; ­this ­would be a com­pen­sa­to­ry ­response to the dam­ag­ing and vas­o­con­strict­ing ­action of LDL.

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