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Panminerva Medica 1999 June;41(2):149-51

lingua: Inglese

Fun­gi of Can­di­da spe­cies in the phar­ynx and ­some param­e­ters of humo­ral and cel­lu­lar immu­nity in ­patients

Kurnatowski P., Kurnatowska A. J.

From the Cen­tre for Treat­ment of Par­a­sit­ic Dis­eas­es and Mycos­es, Depart­ment of Con­ser­va­tive Den­tist­ry, Medical Uni­ver­sity of ­Lodz, ­Poland


Back­ground. The phar­ynx is one of the ­open spac­es ­where fun­gi can set­tle eas­i­ly. The pur­pose of the inves­ti­ga­tion was to esti­mate an over­all prev­a­lence of fun­gal col­o­ni­za­tion and ­some param­e­ters of humo­ral and ­cell immu­nity.
Meth­ods. The ­study con­sist­ed of 167 ­patients, ­from ­whom ­swabs of the pos­te­ri­or and lat­er­al ­part of the phar­ynx ­were tak­en for myco­log­i­cal exam­ina­tions, dur­ing ­which ­tests ­based on mor­pho­log­i­cal and bio­chem­i­cal (zymo­gram, aux­a­no­gram) char­ac­ter­is­tics ­were ­used. In all cas­es, the leu­ko­cyte ­count, over­all pro­tein lev­el, and pro­tein indi­vid­u­al frac­tions ­were deter­mined. ­Also deter­mined ­were the lev­els of IgA, IgM and IgG immu­no­glob­u­lin in ­blood ser­um, and IgA immu­no­glob­u­lin (S-IgA) in sali­va. At the ­same ­time, blas­tic trans­for­ma­tion ­test and ­rosette ­tests: E (ER) to deter­mine lym­pho­cytes T ­count, as ­well as EA (EAR) and EAC (­EACR) to ­detect lym­pho­cytes B, ­were per­formed.
­Results. Fun­gal infec­tion was ­found in 2/3 of ­patients. Fun­gi ­were clas­si­fied as belong­ing to six spe­cies of Can­di­da, ­which are con­sid­ered to be impor­tant etio­log­ical fac­tors of mycos­es; the ­most com­mon fun­gus was Can­di­da albi­cans (in 86 cas­es). All cas­es of can­did­o­sis ­showed a ­decreased ­count of lym­pho­cytes T, ­with ­their func­tion defi­cient, and ­most of ­them a low S-IgA lev­el in sali­va (­over ­three ­times low­er ­than the ­norm) and ­high ­mean val­ues for sed­i­men­ta­tion ­rate.
Con­clu­sions. In ­patients in our ­study the IgA lev­el in ser­um ­remained with­in nor­mal lim­its, yet the ­ratio of ­this frac­tion to oth­er immu­no­glob­u­lins devi­at­ed ­from ­that in ­healthy indi­vid­u­als.

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