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Panminerva Medica 1999 June;41(2):109-13

lingua: Inglese

Biohumoral param­e­ters and ­bone min­er­al con­tent in the iden­tifi­ca­tion of ­high ­risk sub­jects for post­men­o­pau­sal oste­o­por­o­sis

Tavassoli K., Cavalla P., Porcelli A., Surico N.

From the Obstetrics and Gynecology Clinic 2nd Faculty of Medicine and Surgery University of Turin, Italy


Background. The aim of ­this ­study was to eval­u­ate the pos­sibil­ity of iden­ti­fy­ing wom­en ­with a ­high ­risk of post­men­o­pau­sal oste­o­por­o­sis by ­using com­pu­ter­ised ­bone min­er­al anal­y­sis (CBMA) asso­ciat­ed ­with mark­ers of ­bone turn­over in ­order to pro­vide a val­id and reli­able screen­ing ­test.
Methods. A ­total of 925 ­patients ­were eval­u­at­ed, 252 of ­whom had ­already under­gone a pre­lim­i­nary den­sit­o­met­ric ­test six ­months ear­li­er and ­were diag­nosed as ­fast ­bone los­ers. 225 of ­them (89%) ­also ­showed ­altered ­bone turn­over mark­ers. ­CBMA was neg­a­tive in the remain­ing 673 ­patients but 13 ­patients ­showed ­altered ­bone turn­over mark­ers and ­three of the lat­ter ­then ­showed a pos­i­tive ­CBMA 18 ­months lat­er. The 673 ­patients who, ­after six ­months of ­study, ­were not ­fast ­bone los­ers ­were mon­i­tored ­over ­time.
Results. It emerg­es ­from ­these ­results ­that ­fast ­bone los­ers are char­ac­ter­ised by high­er lev­els of hydrox­y­prol­i­nu­ria and cal­cium, low­er lev­els of oes­trone and estrad­i­ol, and ­reduced ­body ­weight com­pared to ­healthy sub­jects.
Conclusions. This sim­pli­fied meth­od ena­bled 79% of the ­fast ­bone los­ers to be iden­ti­fied, where­as den­si­tom­e­try iden­ti­fied 87.5% of the ­high-­risk sub­jects. The ­main advan­tage of our sim­pli­fied meth­od com­pared to the meas­ure­ment of ­bone min­er­al con­tent is ­that it iden­ti­fies the major­ity of ­fast ­bone los­ers in the ­initial post­men­o­pau­sal peri­od, ­before a sub­stan­tial reduc­tion in BMC has tak­en ­place.

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