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Panminerva Medica 1999 June;41(2):109-13

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Biohumoral parameters and bone mineral content in the identification of high risk subjects for postmenopausal osteoporosis

Tavassoli K., Cavalla P., Porcelli A., Surico N.

From the Obstetrics and Gynecology Clinic 2nd Faculty of Medicine and Surgery University of Turin, Italy


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Background. The aim of ­this ­study was to eval­u­ate the pos­sibil­ity of iden­ti­fy­ing wom­en ­with a ­high ­risk of post­men­o­pau­sal oste­o­por­o­sis by ­using com­pu­ter­ised ­bone min­er­al anal­y­sis (CBMA) asso­ciat­ed ­with mark­ers of ­bone turn­over in ­order to pro­vide a val­id and reli­able screen­ing ­test.
Methods. A ­total of 925 ­patients ­were eval­u­at­ed, 252 of ­whom had ­already under­gone a pre­lim­i­nary den­sit­o­met­ric ­test six ­months ear­li­er and ­were diag­nosed as ­fast ­bone los­ers. 225 of ­them (89%) ­also ­showed ­altered ­bone turn­over mark­ers. ­CBMA was neg­a­tive in the remain­ing 673 ­patients but 13 ­patients ­showed ­altered ­bone turn­over mark­ers and ­three of the lat­ter ­then ­showed a pos­i­tive ­CBMA 18 ­months lat­er. The 673 ­patients who, ­after six ­months of ­study, ­were not ­fast ­bone los­ers ­were mon­i­tored ­over ­time.
Results. It emerg­es ­from ­these ­results ­that ­fast ­bone los­ers are char­ac­ter­ised by high­er lev­els of hydrox­y­prol­i­nu­ria and cal­cium, low­er lev­els of oes­trone and estrad­i­ol, and ­reduced ­body ­weight com­pared to ­healthy sub­jects.
Conclusions. This sim­pli­fied meth­od ena­bled 79% of the ­fast ­bone los­ers to be iden­ti­fied, where­as den­si­tom­e­try iden­ti­fied 87.5% of the ­high-­risk sub­jects. The ­main advan­tage of our sim­pli­fied meth­od com­pared to the meas­ure­ment of ­bone min­er­al con­tent is ­that it iden­ti­fies the major­ity of ­fast ­bone los­ers in the ­initial post­men­o­pau­sal peri­od, ­before a sub­stan­tial reduc­tion in BMC has tak­en ­place.

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