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Panminerva Medica 1999 June;41(2):99-101

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Stability of serum TSH concentration after non refrigerated storage

Kolialos G., Gaitatzi M., Grammaticos P.*

From the Department of Biological Chemistry, * Department of Nuclear Medicine, AHEPA General Hospital Medical School Aristotle University of Thessaloniki Thessaloniki, Greece


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Back­ground. The ignor­ance of how sen­si­tive ser­um sam­ples for ­defined ­assays may be, can ­lead to over­pro­tect­ing meas­ures. ­This atti­tude not ­only increas­es ­cost and ­labor in every­day rou­tine but may be respon­sible for not eval­u­at­ing ­series of meas­ure­ments if per­formed in ser­um sam­ples not ­well ­stored.
Meth­ods. Thy­rot­ro­pin (TSH) con­cen­tra­tion in ser­um was test­ed in ­three ­pooled sam­ples ­drawn ­from var­i­ous ­patients, ­before and ­after ­four ­days stor­age at freez­ing (-15°C), low (4°C), and ­room tem­per­a­ture (18-22°C). TSH con­cen­tra­tion was meas­ured in ­each ­part, in 22 rep­li­cates ­using a com­mer­cial ­assay.
­Results. The vari­a­tion of the meas­ured val­ues due to the stor­age con­di­tions was ­less ­than 10%, not exceed­ing the accept­ed ­between ­assay vari­a­tion.
Con­clu­sions. For the esti­ma­tion of TSH con­cen­tra­tion, ­patient ser­um sam­ples may be ­stored up to ­four ­days at 4 °C or ­even at ­room tem­per­a­ture with­out sig­nif­i­cant ­loss of meas­ure­ment accu­ra­cy.

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