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Rivista di Medicina Interna
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Panminerva Medica 1999 Giugno;41(2):93-7
The absence of correlation between immunoregulatory T cells and induced lymphoproliferative response in treated B-chronic lymphocytic leukemia patients
Milosevic D., Marinkovic M., Colovic M.*, Jelic S.
From the Institute for Oncology and Radiology of Serbia, Belgrade, Yugoslavia
* Institute of Haematology, University Clinical Center, Belgrade, Yugoslavia
Background. Many data suggest T cell functional impairment in B-cell chronic lymphocytic leukemia (B-CLL). The mechanism responsible for this phenomenon is still unresolved.
Methods. In 88 B-CLL patients (RAI II-IV) the relationship between immunoregulatory T cells and PHA induced lymphoproliferative response (LPR) was analysed before and after the therapy. The number of peripheral blood CD3+, CD4+ and CD8+ T lymphocytes was determined by indirect immunofluorescence assay using monoclonal antibodies. LPR was estimated in whole blood culture method.
Results. The absolute number of CD3+,CD4+ and CD8+ cells in untreated CLL patients was much higher than in healthy controls (n=26), but the percentages of these subpopulations, CD4/CD8 ratio and LPR to PHA were significantly (p<0.00001) decreased. The chemotherapy induced a significant rise of CD3+ and CD4+ percentages (p<0.006