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FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOPANMINERVA MEDICA

Rivista di Medicina Interna


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Panminerva Medica 1999 Marzo;41(1):59-61

 CASE REPORTS

Rap­id evo­lu­tion of chron­ic ­viral hep­a­titis into hepat­o­cel­lu­lar car­ci­no­ma ­after ­beta-inter­fer­on treat­ment

Malaguarnera M., Restuccia S., Di Fazio I., Di Marco R., Pistone G., Trovato B. A.

From the Depart­ment of Inter­nal Med­i­cine and Ger­i­at­rics Uni­ver­sity of Cata­nia, Ita­ly

A 62-­year-old man, affect­ed by Chron­ic ­Active Hep­a­titis (dis­cov­ered in 1993) and treat­ed ­with inter­fer­on, ­referred to our depart­ment ­with ­increased abdom­i­nal vol­ume, per­sis­tent abdom­i­nal ­pain, con­tin­u­ous-remit­tent ­fever and jaun­dice. CT ­scan of the liv­er ­revealed a hypo­dense, not cap­su­lat­ed, infil­tra­tive, sol­id for­ma­tion in the ­right ­lobe. US guid­ed biop­sy ­showed mul­ti­nu­cle­at­ed ­giant ­cells, ­with eosin­o­phil­ic cyto­plasm and ple­o­mor­phism of the ­nuclei, ­arranged in sev­er­al ­thick trab­e­cu­la ­lined by endo­the­lial ­cells or ­formed ­bile con­tain­ing aci­ni. In our ­case, the rap­id evo­lu­tion of chron­ic ­viral hep­a­titis ­towards HCC ­calls for a care­ful eval­u­a­tion of the ­role of IFN ther­a­py, ­since ­this ­drug is wide­ly ­used in chron­ic liv­er dis­eas­es.

lingua: Inglese


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