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Rivista di Medicina Interna
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Panminerva Medica 1999 March;41(1):31-4
Effect of renal transplantation (surgical stress) on serum levels of oxidants and reducing system
Rajbala A., Sane A. S., Shah P. R.*, Mishra V. V.**, Patel S. M.***, Shah S. A. ***, Shah V. R.°, Trivedi H. L.
From Department of Laboratory Medicine (Biochemistry) *Nephrology, **High Risk Pregnancy, ***Urology °Anaesthesiology Institute of Kidney Diseases and Research Centre, Ahmedabad, India
Background. This study attempts to understand the correlation (if any) between surgical stress of renal transplantation and serum levels of pro-oxidant/antioxidants.
Methods. Twenty-four ESRD patients having undergone transplant surgery followed from day-1 to day-10 postsurgery were investigated for serum levels of MDA, SOD, Vit. C and E. The drug regimen received was immunosuppressant, H2 blockers and antihypertensives as per the situation.
Results. The typical observations indicated elevated serum levels of MDA from preoperative stage reaching peak value 24 hrs after surgery followed by a steady fall and achieving minima on the 10th day. As regards antioxidants enzyme SOD, Vit. C, Vit. E were low from pretransplant day reaching minima 24 hours postoperatively and returning to normal from 7th day.
Conclusions. The present investigation has amply shown a typical imbalance between pro-oxidant/antioxidants from pre-transplant day up to 24 hrs and there after returning to normal level from 7th day suggestive of desired recovery and surgical stress not a limiting factor in way of health progress renal transplant. Dietary intake of Vit. C and E in mega doses can be a good therapeutic measure.