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Panminerva Medica 1998 September;40(3):196-8

lingua: Inglese

Does endo­the­lin-1 ­play a ­role in the ­renal func­tion of cir­rhot­ic ­patients?

Bruno C. M., D'Amico R., Ierna D., Neri S.

From the Insti­tute of Inter­nal and Emer­gen­cy Med­i­cine University of Catania, Catania, Ita­ly


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Meth­ods. We inves­ti­gat­ed plas­ma and uri­nary endo­the­lin-1 lev­els in ­eleven cir­rhot­ic ­patients and ten ­healthy con­trol sub­jects, to eval­u­ate wheth­er endo­the­lin is ­involved in ­renal func­tion­al alter­a­tions of liv­er cir­rho­sis.
­Results. No sig­nif­i­cant dif­fer­ence in plas­ma ET-1 lev­els was ­observed ­between the two ­groups (p>0.05) but uri­nary ET-1 excre­tion was sig­nif­i­cant­ly high­er in cir­rhot­ics ­than in con­trols (p<0.001). Crea­ti­nine clear­ance (­mean 56±7.6 ml/min) ­showed an ­inverse cor­re­la­tion ­with plas­ma ET-1 lev­els (p<0.05) in cir­rhot­ics.
Con­clu­sions. We ­believe ­this may be ­caused by ­enhanced ­local ET-1 activ­ity ­linked to an up-reg­u­la­tion of its spe­cif­ic recep­tors and/or ­increased ­renal syn­the­sis, result­ing in aug­ment­ed uri­nary excre­tion.

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