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Rivista di Medicina Interna
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Panminerva Medica 1998 Settembre;40(3):196-8
Does endothelin-1 play a role in the renal function of cirrhotic patients?
Bruno C. M., D'Amico R., Ierna D., Neri S.
From the Institute of Internal and Emergency Medicine University of Catania, Catania, Italy
Methods. We investigated plasma and urinary endothelin-1 levels in eleven cirrhotic patients and ten healthy control subjects, to evaluate whether endothelin is involved in renal functional alterations of liver cirrhosis.
Results. No significant difference in plasma ET-1 levels was observed between the two groups (p>0.05) but urinary ET-1 excretion was significantly higher in cirrhotics than in controls (p<0.001). Creatinine clearance (mean 56±7.6 ml/min) showed an inverse correlation with plasma ET-1 levels (p<0.05) in cirrhotics.
Conclusions. We believe this may be caused by enhanced local ET-1 activity linked to an up-regulation of its specific receptors and/or increased renal synthesis, resulting in augmented urinary excretion.