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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,6
Online ISSN 1827-1898
Bruno C. M., D'Amico R., Ierna D., Neri S.
From the Institute of Internal and Emergency Medicine University of Catania, Catania, Italy
Methods. We investigated plasma and urinary endothelin-1 levels in eleven cirrhotic patients and ten healthy control subjects, to evaluate whether endothelin is involved in renal functional alterations of liver cirrhosis.
Results. No significant difference in plasma ET-1 levels was observed between the two groups (p>0.05) but urinary ET-1 excretion was significantly higher in cirrhotics than in controls (p<0.001). Creatinine clearance (mean 56±7.6 ml/min) showed an inverse correlation with plasma ET-1 levels (p<0.05) in cirrhotics.
Conclusions. We believe this may be caused by enhanced local ET-1 activity linked to an up-regulation of its specific receptors and/or increased renal synthesis, resulting in augmented urinary excretion.