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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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From the Department of Gastroenterology and Digestive Endoscopy San Martino Hospital, Genova, Italy
Background. Some authors reported the relationship between Helicobacter pylori (HP) prevalence and gastric cancer incidence.
It is generally agreed that HP plays a key role in altering regulatory factors affecting cellular proliferation during the disease process. This hyperproliferation is due, mainly, to active inflammation action on glandular neck cells. Neoplastic changes may arise owing to a loss of control of cell proliferation.
Methods. In the present study it has been evaluated the muco-peptic cells (immature cells) expansion in surrounding areas of body-fundic intestinal type advanced gastric cancer (GC) in patients with non atrophic gastritis: the cases have been subdivided in relation with HP infection.
Results. Muco-peptic expansion was present in 73.9% of HP positive GC patients. The cell expansion has not been observed either in HP negative GC or in control subjects.
Conclusions. The phenomenon, a morphological manifestation of hyperproliferation, might overexpose the mucosa to environmental factors. Therefore, in subjects with genetic predisposition, HP could act as a promoter in the progression towards neoplasia independently of chronic atrophic gastritis.