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Panminerva Medica 1998 September;40(3):169-73

lingua: Inglese

Hypertension and relat­ed ­risk fac­tors in ­type 2 dia­betes mel­lit­us

Lunetta M., Barbagallo A., Crimi S., Di Mauro M., Sangiorgio L., Mughini L.

From the Chair of Metabolic Diseases, Department of Internal Medicine, Endocrinology and Metabolism University of Catania, Catania, Italy


Methods. The cor­re­la­tion ­between hyper­ten­sion and relat­ed ­risk fac­tors has ­been stud­ied in 733 ­type 2 dia­bet­ic ­patients. Hypertension was ­more fre­quent in wom­en (65.35%) ­than in men (50.35%) (p<0.0001).
Results. Hypertensive ­patients ­showed old­er age (p<0.0001) and great­er Body Mass Index (BMI) (p<0.03) ­than nor­mo­ten­sive. In the dia­bet­ic ­group on ­diet ­only ­basal insu­li­nae­mia was high­er (p<0.05) in hyper­ten­sive ­than in nor­mo­ten­sive dia­bet­ic men, but not in wom­en. Such a dif­fer­ence, was not ­seen in ­patients of ­both sex­es treat­ed ­with ­oral hypo­gly­caem­ic ­agents; ­besides ­there was no dif­fer­ence in fast­ing C-pep­tide lev­els ­between hyper­ten­sive and nor­mo­ten­sive insu­lin treat­ed ­patients. In ­both sex­es hyper­ten­sion was inde­pen­dent­ly cor­re­lat­ed ­with age, BMI, ­increased uri­nary albu­min excre­tion, tri­gly­ce­rides. The strong­est cor­re­la­tion was ­with the fam­i­ly his­to­ry of hyper­ten­sion. On the con­trary ­there was no cor­re­la­tion ­between hyper­ten­sion and ­waist-hip ­ratio.
Conclusions. In con­clu­sion, the asso­ci­a­tion ­between hyper­ten­sion and ­type 2 dia­betes ­depends on var­i­ous ­risk fac­tors, but a rela­tion­ship ­with insu­lin lev­els is not sure­ly demon­strable.

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