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Panminerva Medica 1998 March;40(1):51-4

lingua: Inglese

Nitric oxide plas­ma lev­els in ­patients with chron­ic and acute cereb­ro­vas­cu­lar dis­or­ders

Ferlito S., Gallina M., Pitari G. M.*, Bianchi A.*

From the Chair of Medical Semeiology and Methodology II Chair of Pharmacology University of Catania, Italy


Background. The ­authors car­ried out a study on plas­ma level of ­nitrites, ­stable end-prod­ucts of ­nitric oxide, aimed at inves­ti­gat­ing some fea­tures of the cere­bral micro­vas­cu­lar func­tion in chron­ic and acute cereb­ro­vas­cu­lar dis­or­ders.
Methods. The ­series con­sists of 16 ­patients with chron­ic cere­bral vas­cu­lar dis­ease, 11 ­patients with TIA, 28 ­patients with throm­bot­ic ­stroke and 27 nor­mal con­trols; the diag­no­sis was done on the basis of clin­i­cal, ultra­son­o­graph­ic and tomod­en­sit­o­met­ric find­ings.
For each sub­ject the deter­mi­na­tion of ­nitrate plas­ma lev­els by a meth­od based on the color­imet­ric reac­tion (devel­oped by ­nitrites dis­solved in an acid solu­tion con­tain­ing sul­fa­nil­a­mide) was per­formed; this reac­tion ­yields quan­ti­ta­tive ­results exact­ly cor­re­spond­ing to the ­amount of ­nitric oxide.
Results. In chron­ic cereb­ro­vas­cu­lar ­patients NO2- val­ues ten­den­ti­al­ly high­er (16.4±0.52 µmol/l) but not sta­tis­ti­cal­ly dif­fer­ent from those of con­trols (13.2±0.52) were ­obtained; also the val­ues found in the group with TIA, even if slight­ly ­reduced (8.0±1.4 µmol/l), did not dif­fer from con­trols; in the ­stroke group a sig­nif­i­cant (p<0.05) reduc­tion (6.4±0.52 µmol/l), as com­pared to con­trols, was found.
Conclusions. On the basis of these ­results and of the lit­er­a­ture data on the phys­io­path­o­log­i­cal pro­file of NO, the ­authors sug­gest a com­pen­sa­to­ry ­increase of the basal tone of NO in chron­ic cereb­ro­vas­cu­lar diseases, while an ­impaired endo­the­lial syn­the­sis of the mark­er could play a crit­i­cal role in TIA ­patients and more evi­dent­ly in ­stroke ­patients, pre­sent­ing a wide micro­vas­cu­lar area com­plete­ly and irre­ver­sibly exclud­ed.

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