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Panminerva Medica 1998 Marzo;40(1):41-4

lingua: Inglese

Preoperative ­GnRH ana­logue in hys­ter­os­cop­ic met­ro­plas­ty

Colacurci N., De Franciscis P., Mollo A., Mele D., Fortunato N., Zarcone R.

From ­the Department of Gynaecology ­and Obstetrics School of Medicine Second University of Naples, Naples, Italy


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Objective. To eval­u­ate ­the effec­tive­ness of Gonadotropin-Releasing Hormone ana­logue ­when admin­is­tered pre­op­er­a­tive­ly in hys­ter­os­cop­ic met­ro­plas­ty.
Design. Prospective, com­par­a­tive ­study.
Patients ­and ­main out­come meas­ures. Sixty ­patients under­go­ing hys­ter­os­cop­ic met­ro­plas­ty ­for sep­tate uter­us ­who ­were random­ly allo­cat­ed to pre­treat­ment ­with ­two injec­tions month­ly of Gonadotropin-Releasing Hormone ana­logue or to no pre­treat­ment. To ­assess ­the out­come of sur­gery ­three param­e­ters ­were ­used: oper­a­tive ­time (min­utes), ­fluid adsorp­tion (ml) ­and intra­op­er­a­tive bleed­ing.
Results. No sig­nif­i­cant dif­fer­enc­es in ­the oper­at­ing ­time (21.9 vs 22.9 ­min), ­fluid adsorp­tion (395 ml, ­range 200-550 vs 515 ml, ­range 250-650), intra­op­er­a­tive bleed­ing ­and fail­ure ­rate ­were ­found ­between pre­treat­ed ­patients ­and con­trols.
Conclusions. Preoperative treat­ment ­with Gonadotropin-Releasing Hormone ana­logue ­showed no advan­tage in hys­ter­os­cop­ic treat­ment of mul­ler­ian ­defects, ­but ­only an improve­ment, ­not sta­tis­ti­cal­ly sig­nif­i­cant, in ­term of ­reduced oper­a­tive ­time ­and ­fluid adsorp­tion.

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