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Rivista di Otorinolaringologia, Chirurgia Maxillo-Facciale,
Chirurgia Plastica Ricostruttiva, Otoneurochirurgia
Indexed/Abstracted in: EMBASE, Scopus
Otorinolaringologia 2014 Giugno;64(2):79-99
Probiotics in allergic rhinitis: myth or reality? A systematic review and meta-analysis
Lauriello M. 1, Salvi I. 2, Mattei A. 3, Angelone A. M. 3, Fioretti A. B. 1, Fusetti M. 1
1 Department of Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy;
2 ENT Department-San Salvatore Hospital, L’Aquila, Italy;
3 Department of Internal Medicine and Public Health, University of L’Aquila, L’Aquila, Italy
AIM: A review of the scientific evidence for the use of probiotics in allergic rhinitis (AR).
METHODS: The studies reviewed have been collected from the PubMed and Cochrane Trial Register databases. According to EBM criteria, the included studies were randomized, double-blind and placebo controlled (RCTs). The research covered the period from 2000 to 2011. According to the inclusion criteria, 23 articles were found.
RESULTS: Seventeen studies evaluated the clinical parameters of AR: the severity of symptoms improved in 14 RCTs while neither improvement nor worsening was recorded in 3 RCTs from a clinical point of view. Twenty studies evaluated the laboratory parameters of AR. The immunological parameters were influenced in different ways by the use of probiotics. The fluctuations of the gut microbiota, that normally occur during the pollen season in allergic patients, were inhibited by the use of these agents. The meta-analysis was performed for IgE levels outcomes, in 4 trials, and for the number of bifidobacteria in the fecal microbiota outcomes, in 3 trials, using probiotics –treated groups and control groups.
CONCLUSION: Systematic review would seem to suggest the validity of probiotics in the treatment of allergic rhinitis. The results of the meta-analysis, currently, do not show sufficient evidence.