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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2014 Sep 05
The efficacy of radioiodine remnant ablation for differentiated thyroid cancer patients with an incomplete thyroidectomy
Fu H., Ma C., Li J., Feng F., Wu S., Ye Z., Wang H. ✉
Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
AIM: To evaluate the efficacy of RRA for DTC patients with an incomplete thyroidectomy.
METHODS: The medical histories of post-surgical DTC patients who accepted RRA between 2010 and 2012 were retrospectively reviewed. Among them, 113 patients who had undergone a total or near-total thyroidectomy comprised the complete thyroidectomy group (CT group) and the remaining 40 patients who had undergone a lobectomy or sub-total thyroidectomy comprised the incomplete thyroidectomy group (ICT group). The difference in the patients’ age, gender, histology, serum TSH level and 24hr RIU between the two groups was analyzed by chi-square test or ANOVA. The efficacy of RRA in ICT group was evaluated by comparing its rate of complete ablation after the first RRA and its cumulative rate of complete ablation after the second RRA to the rate of complete ablation after the first RRA in CT group respectively by chi-square test.
RESULTS: 1. Of all the clinical characteristics, only serum TSH level and 24hr RIU have significant difference between two groups (p<0.01 for both). 2. The rate of complete ablation after the first RRA was 67.26% in CT group. The rate of complete ablation after the first RRA and the cumulative rate of complete ablation after the second RRA was 27.50% and 67.50% respectively in ICT group. 3. The ablative rate of the first RRA between the two groups was compared by chi-square test and the difference was significant (p<0.01). The ablative rate of the first RRA in CT group was compared with the cumulative rate of the second RRA in ICT group and the difference was not significant (p=0.978).
CONCLUSION: Although the efficacy of RRA in DTC patients with an incomplete thyroidectomy is not as good as that of patients with a complete thyroidectomy after the first RRA, a higher ablative rate can still be achieved after the second or third RRA.