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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2014 Mar 20

Copyright © 2014 EDIZIONI MINERVA MEDICA

lingua: Inglese

68Ga-citrate PET/CT in tuberculosis: a pilot study

Vorster M. 1, Maes A. 2, Van de Wiele C. 3, Sathekge M. M. 1

1 University of Pretoria, Department of Nuclear Medicine, Steve Biko Academic Hospital; 2 Department of Nuclear Medicine AZ Groeninge, Reepkaai, Kortrijk, Belgium; 3 Department of Nuclear Medicine, University hospital Ghent, Ghent, Belgium


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Aim: Tuberculosis remains an important cause of morbidity and mortality worldwide, the diagnosis, staging and treatment response evaluation of which remains suboptimal. We evaluated PET/CT imaging with a novel tracer,68Ga-citrate, in this setting.
Methods: Thirteen patients with tuberculosis underwent PET/CT imaging with 68Ga-citrate. Tuberculosis was diagnosed with bacteriological or histopathology studies (n=8) or based on a combination of clinical data, biochemistry and imaging (n=5). PET images were analyzed qualitatively and semi-quantitatively and compared to CT findings.
Results: All 13 patients demonstrated abnormal tracer accumulation in the lungs or extrapulmonary or both. 68Ga-citrate accumulated in every lung lesion noted on CT in six cases (46%). In seven cases (54%) some of the lung lesions noted on CT were not 68Ga-citrate avid, which is suggestive of non-active tuberculous lesions. Ten patients (77%) demonstrated extra-pulmonary involvement, which included various lymph node groups, skeletal lesions, pleural-, splenic- and gastro-intestinal tract involvement. Detection of extra-pulmonary involvement was higher on PET compared to CT (more lesions detected) in eight cases (80%).
Conclusion: 68Ga-citrate PET accumulates in both pulmonary and extra-pulmonary tuberculous lesions and may provide a way of distinguishing active from inactive lesions for treatment response evaluation. 68Ga-citrate PET may be superior to CT in the detection of extra-pulmonary involvement.

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mike.sathekge@up.ac.za