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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2016 March;60(1):25-39

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Morphology supporting function: attenuation correction for SPECT/CT, PET/CT, and PET/MR imaging

Tzu C. LEE 1, Adam M. ALESSIO 1, 2, Robert M. MIYAOKA 2, Paul E. KINAHAN 1, 2

1 Department of Bioengineering, University of Washington, Seattle, WA, USA; 2 Department of Radiology, University of Washington, Seattle, WA, USA


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Both SPECT, and in particular PET, are unique in medical imaging for their high sensitivity and direct link to a physical quantity, i.e. radiotracer concentration. This gives PET and SPECT imaging unique capabilities for accurately monitoring disease activity for the purposes of clinical management or therapy development. However, to achieve a direct quantitative connection between the underlying radiotracer concentration and the reconstructed image values several confounding physical effects have to be estimated, notably photon attenuation and scatter. With the advent of dual-modality SPECT/CT, PET/CT, and PET/MR scanners, the complementary CT or MR image data can enable these corrections, although there are unique challenges for each combination. This review covers the basic physics underlying photon attenuation and scatter and summarizes technical considerations for multimodal imaging with regard to PET and SPECT quantification and methods to address the challenges for each multimodal combination.

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Kinahan@uw.edu