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A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
Online ISSN 1827-1936
Morbelli S. 1, Ghigliotti G. 2, Spinella G. 3, Marini C. 4, Bossert I. 1, Cimmino M. A. 5, Pane B. 3, Rousas N. 3, Cittadini G. 6, Massollo M. 1, Camellino D. 5, Riondato M. 1, Palombo D. 3, Barisione C. 7, Sambuceti G. 1
1 Nuclear Medicine Unit, IRCCS San Martino University Hospital ‑ IST, Dept of Health Sciences, University of Genoa, Genoa, Italy;
2 Cardiology and Laboratory of Cardiovascular Biology, IRCCS San Martino University Hospital ‑ IST, University of Genoa, Genoa, Italy;
3 Division of Vascular and Endovascular Surgery, IRCCS San Martino University Hospital ‑ IST, University of Genoa, Genoa, Italy;
4 CNR Institute of Bioimages and Molecular Physiology, Milan, Section of Genova, Italy;
5 Rheumatology Unit, IRCCS San Martino University Hospital ‑ IST, University of Genoa, Genoa, Italy;
6 Department of Radiology, IRCCS San Martino University Hospital ‑ IST, University of Genoa, Genoa, Italy;
7 IRCCS San Martino University Hospital, Research Centre of Cardiovascular Biology, University of Genoa, Genoa, Italy
AIM: The aim of this paper was to investigate the presence of systemic vascular inflammation and its relationship with risk factors and biomarkers of systemic inflammation related to atherosclerosis in asymptomatic abdominal aortic aneurysm (AAA) patients.
METHODS: Thirty AAA patients and 30 age-matched controls underwent contrast-enhanced 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT. C-reactive protein, erythrocyte sedimentation rate, white blood cell count and differential, serum fibrinogen, D-dimer and full lipid panel were also evaluated. Region of interest analyses were performed to obtain target-to-background (TBR) metabolism of aorta, subclavian, carotid, iliac arteries and AAA. CT-based arterial calcium load (CL) was evaluated. Arterial Metabolism and CL intergroup differences were tested (unpaired t-test). Linear regression analysis was performed only between blood biomarkers on one side and both TBR and ACL of the arterial districts that resulted significantly different between patients and controls on the other. In all the analyses P values <0.05 were considered significant.
RESULT: FDG-uptake was higher with respect to controls in aorta, carotid and iliac arteries (P<0.01, P<0.007, P<0.04 respectively). AAA and aorta metabolism showed an inverse correlation with HDL-chol (P<0.02 and P<0.01, respectively) while only aorta showed a direct correlation with lymphocytes’ count (P<0.02). Carotid metabolism was directly correlated with monocytes’ count and C-reactive protein concentration (P<0.02 and P<0.004, respectively).
CONCLUSION: The present findings support the relevance of systemic vascular inflammation in all phases of atherosclerosis-related disorders. Moreover they confirm the concept that acute ischemic syndromes might represent the local result of a systemic inflammation rather than the focal involvement of a single arterial lesion.