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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2014 Settembre;58(3):276-83

lingua: Inglese

NK cell imaging by in vitro and in vivo labelling approaches

Galli F. 1, Histed S. N. 2, Aras O. 3

1 Nuclear Medicine Unit, Faculty of Medicine and Psychology, Department of Medical‑Surgical Sciences and Translational Medicine, University of Rome La Sapienza, Rome, Italy;
2 Department of Radiology, University of California, Los Angeles, CA, USA
3 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA


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Natural killer (NK) cells are a particular lymphocyte subset with a documented cytotoxic activity against cancer cells. Evidence of NK antitumoral effect led researchers to focus on the development of immunotherapies aimed at augmenting NK recruitment and infiltration into tumor and their anti-cancer functions. Studies in animal models proved that the right combination of drugs, cytokines, chemokines and other factors might be used to enhance or suppress tumor targeting by NK cells. Therefore, it would be necessary to have a tool to non-invasively monitor the efficacy of such novel therapies. Available imaging techniques comprise magnetic resonance, optical and nuclear medicine imaging with a pool of compounds that ranges from radiolabelled nanoparticles and radiopharmaceuticals to fluorescent probes. Each tracer and technique has its own pros and cons, but till now, no one emerged as superior among the others.

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araso@mskcc.org