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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2012 Giugno;56(3):280-90

lingua: Inglese

Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging

Spinelli A. E. 1, Marengo M. 2, Calandrino R. 1, Sbarbati A. 3, Boschi F. 3

1 Medical Physics Department, San Raffaele Scientific Institute, Milan, Italy;
2 Medical Physics Department, S. Orsola-Malpighi University Hospital, Bologna, Italy;
3 Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona, Italy


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In this review there will be presented an overview of the literature about the recent developments on radiotracers imaging using optical methods and their applications. We will begin with a short summary regarding the discovery of Cerenkov radiation (CR) and then focus on the early developments and experimental validation of planar Cerenkov luminescence imaging. A significant improvement in Cerenkov luminescence imaging was given by the development of tomographic methods in order to obtain in vivo whole body 3D images of Cerenkov sources. An interesting and original application discussed in this review is the use of CR as the excitation source of quantum dots and fluorophores. We will also present some recent experimental results on in vivo radio luminescence imaging of alpha and gamma emitters. All these results make optical radioisotopes imaging an interesting cost-effective tool for the screening of new probes for both imaging and therapeutic applications. Other interesting aspects are the uses of Cerenkov radiation for radiotherapy and for radiopharmaceuticals synthesis applications. We will conclude by summarising the most important results and the future challenges.

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spinelli.antonello@hsr.it