Home > Riviste > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Fascicoli precedenti > The Quarterly Journal of Nuclear Medicine and Molecular imaging 2011 April;55(2) > The Quarterly Journal of Nuclear Medicine and Molecular imaging 2011 April;55(2):155-67

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413


eTOC

 

  DOSIMETRY IN NUCLEAR MEDICINE - PART II


The Quarterly Journal of Nuclear Medicine and Molecular imaging 2011 April;55(2):155-67

Copyright © 2011 EDIZIONI MINERVA MEDICA

lingua: Inglese

Recent issues on dosimetry and radiobiology for peptide receptor radionuclide therapy

Cremonesi M., Ferrari M., Di Dia A., Botta F., De Cicco C., Bodei L., Paganelli G.

European Institute of Oncology, Milan, Italy


PDF  


Peptide receptor radionuclide therapy (PRRT) has been constantly evolving over the last decade, providing successful results in the treatment of tumors expressing somatostatin receptors, especially with 90Y ‑ and 177Lu ‑ radiolabelled peptides. Recent and/or ongoing studies assure new perspectives to come. Dosimetry represents a precious guide for the selection of radionuclides and peptides, for protocol settings, for toxicity prevention and therapy optimization. Thus, reliable and personalized dosimetry is more and more requested. This paper reviews the important advances recently obtained in the dosimetric methods that have been applied to this therapy. Special emphasis has been given to the impact derived (or derivable in the next future) from more refined dose evaluations focused on the kidneys and the red marrow. The possibility of improving the accuracy of dosimetry represents a further challenge for this therapy. Following the preliminary correlation observed between the biological effective dose and the probability of renal injury, more reliable dose estimates could definitively enhance the predicitivity of the radiobiological effects, for toxicity prevention as well as for tumor control.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail

marta.cremonesi@ieo.it