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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
The Quarterly Journal of Nuclear Medicine and Molecular imaging 2011 February;55(1):66-71
Imaging the inflammatory activity of sarcoidosis: sensitivity and inter observer agreement of 67Ga imaging and 18F-FDG PET
Keijsers R. G. 1, Grutters J. C. 2, Thomeer M. 3, Du Bois R. M. 4, Van Buul M. M. 1, Lavalaye J. 1, Van Den Bosch J. M. 2, Verzijlbergen F. J. 1 ✉
1 Department of Nuclear Medicine, St Antonius Hospital, Nieuwegein, the Netherlands;
2 Department of Pulmonology, St Antonius Hospital, Nieuwegein, the Netherlands;
3 Department of Pulmonology, Universitaire Ziekenhuizen Leuven, Ziekenhuis Oost-Limburg, Belgium;
4 Pulmonary and Occupational and Environmental Health Divisions, National Jewish Health, Denver, CO, USA
AIM: The aim of this study was to investigate sensitivity of 67Ga imaging and 18F-FDG PET for sarcoidosis activity and their inter observer variability.
METHODS: Thirty-four newly diagnosed, histologically proven sarcoidosis patients were analyzed prospectively. 67Ga imaging and 18F-FDG PET were performed, the presence of pulmonary and extra pulmonary lesions was evaluated and inter observer variability of both techniques was assessed.
RESULTS: Overall sensitivity to detect active sarcoidosis was 88% for 67Ga imaging and 97% for 18F-FDG PET. Although these results were not significantly different, 18F-FDG PET detected more lesions in the mediastinum (P<0.05), hila (P<0.05), lymph nodes (P<0.001) and extra pulmonary regions in general (P<0.001). Inter observer agreement was poor to moderate for 67Ga imaging (kappa 0.19-0.59) and good to very good for 18F-FDG PET (kappa 0.65-1.00).
CONCLUSION: 18F-FDG PET is more sensitive than 67Ga imaging in the assessment of sarcoidosis activity with regard to the mediastinum, hila, lymph nodes and extra pulmonary lesions in general.
Furthermore, 18F-FDG PET demonstrates a very good inter observer agreement in contrast with 67Ga imaging and 18F-FDG PET is therefore the nuclear imaging technique of choice in sarcoidosis assessment.