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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
ORIGINAL ARTICLES MOLECULAR IMAGING BEYOND NUCLEAR MEDICINE
The Quarterly Journal of Nuclear Medicine and Molecular imaging 2009 December;53(6):646-57
Differences in hippocampal metabolism between amnestic and non-amnestic MCI subjects: automated FDG-PET image analysis
Clerici F. 1, Del Sole A. 2, Chiti A. 3, Maggiore L. 1, Lecchi M. 2, Pomati S. 1, Mosconi L. 4, Lucignani G. 2, Mariani C. 1 ✉
1 Center for Research and Treatment of Cognitive Dysfunctions, Institute of Clinical Neurology Department of Clinical Sciences
University of Milan, “Luigi Sacco” Hospital, Milan, Italy;
2 Unit of Nuclear Medicine, Institute of Radiological Sciences University of Milan, Hospital San Paolo, Milan, Italy;
3 Department of Nuclear MedicineClinical Institute Humanitas, Rozzano, Milan, Italy;
4 Department of Psychiatry, New York University School of Medicine, New York, NY, USA
AIM: The aim of this study was to assess whether 18F-fluorodeoxyglucose positron emission tomography differentiates amnestic (aMCI) from single-non-amnestic mild cognitive impairment (snaMCI) with executive dysfunction.
METHODS: Sixteen aMCI subjects (62% females, age 75±8 years) and 14 snaMCI subjects (71% females, age 74±6 years) underwent [18F]FDG-PET and clinical follow-up. Comparisons between MCI subgroups and with seven cognitively normal elderly subjects were performed using SPM2.
RESULTS: At baseline aMCI and snaMCI exhibited a similar pattern of hypometabolism, mostly in the posterior cingulate gyrus, as compared with controls. In the comparison between the MCI subtypes, the aMCI subjects showed reduced metabolism in the medial temporal lobes (MTL) (hippocampus, fusiform gyrus and amygdala). At follow-up 12 aMCI developed Alzheimer’s disease (AD), while snaMCI had a heterogeneous course, including five subjects who developed Lewy body dementia.
CONCLUSIONS: The patterns of altered brain metabolism in aMCI and snaMCI subjects compared to controls are similar and do not provide evidence for making clinical distinctions between them. Comparison between the two MCI subtypes showed MTL hypometabolism in aMCI subjects, possibly reflecting the fact that most had prodromal AD.