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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
ORIGINAL ARTICLES LATEST ADVANCES IN RADIOPHARMACOLOGY AND RADIOPHARMACY 2009
The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2009 Agosto;53(4):422-7
What are the preoperative factors that can determine the presence of metastases in other axillary nodes in breast cancer when the sentinel node is positive?
Domènech A. 1, Benítez A. 1, Bajén M. T. 1, Ricart Y. 1, Rodríguez-Gasén A. 1, Palacín J. A. 2, Català I. 3, Gil M. 4, Pernas S. 4, García A. 5, Martín-Comín J. 1 ✉
1 Department of Nuclear Medicine, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain;
2 Department of Plastic Surgery, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain;
3 Department of Pathology, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain;
4 Department of Oncology, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain;
5 Department of Gynecology, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain
AIM:. To determine whether preoperative factors, such as size of metastases in the sentinel lymph node (SLN), number of positive SLNs (1, >1), tumoral grade, lymphovascular invasion (LVI) and tumoral size can predict the presence of metastases in non-SLNs, when the SLN is positive-.
METHODS:The study population was 1 146 breast cancer patients. Lymphadenectomy was performed in 150. Three groups of patients were established depending on the size of the metastases in SLNs: group A: <2 mm; group B: 2 ≤GC ≤5 mm; group C: >5 mm. Either the c2 test or Fisher’s test was performed to compare categorical variables, and a multivariate conditional logistic regression model for data sets was performed to identify the deterministic factors of metastases presence.
RESULTS:Ten percent of group A, 28% of group B and 52% of group C presented non-SLN metastases. Patients with >1 positive-SLN presented significantly more non-SLN metastases than those with only one positive-SLN; 56% of patients with LVI presented non-SLN metastases versus 26% of those without LVI. The tumoral grade and size did not seem to have any influence on the number of patients with non-SLN metastases. The number of positive-SLNs and size of metastases were statistically associated with the presence of metastases.
CONCLUSIONS. In this study population, the probability of finding non-SLN metastases was statistically related to the size of the SLN metastases and the number of positive-SLNs.