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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Rivista di Medicina Nucleare e Imaging Molecolare
A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
Impact Factor 2,413
ORIGINAL ARTICLES LATEST ADVANCES IN RADIOPHARMACOLOGY AND RADIOPHARMACY 2009
The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2009 August;53(4):417-21
Incidental detection by [11C]choline PET/CT of meningiomas in prostate cancer patients
Fallanca F., Giovacchini G., Picchio M., Bettinardi V., Messa C., Fazio F. ✉
1 Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
2 Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy
3 Department of Nuclear Medicine, San Gerardo Hospital, Monza, Italy
4 IBFM-CNR, Milan, Italy
AIM: Anti-androgenic hormonal therapy in prostate cancer patients with concomitant meningioma may result in tumor growth and development of neurological symptoms. Positron emission tomography/computed tomography (PET/CT) with [11C]choline is used for restaging prostate cancer patients with biochemical failure. In vitro and in vivo data support altered choline metabolism in meningiomas.
METHODS.During a retrospective study in prostate cancer patients with biochemical failure referred to our institution between November 2004 and Ja-nuary 2007, encephalic focal uptake of [11C]choline was incidentally noted in 4 patients, 2 of which had been taking luteinizing hormone-releasing hormone analogs.
RESULTS: Subsequent to the incidental finding, one patient underwent surgical removal of the meningioma; strict neuroradiological follow-up was planned for the 3 other patients.
CONCLUSIONS. We suggest that in prostate cancer patients candidate for anti-androgenic therapy the whole body [11C]choline PET/CT scan should include the whole skull to check for the possible presence of meningiomas. This could help to identify patients at risk for the development of neurological symptoms during anti-androgenic therapy and help the referring urologist in the clinical management of these patients.